IQGAP2

Ras GTPase-activating-like protein IQGAP2 is an enzyme that in humans is encoded by the IQGAP2 gene.

IQGAP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3IEZ, 4EZA
Identifiers
Aliases	IQGAP2, IQ motif containing GTPase activating protein 2
External IDs	OMIM: 605401; MGI: 2449975; HomoloGene: 101543; GeneCards: IQGAP2; OMA:IQGAP2 - orthologs
Gene location (Human) Chr. Chromosome 5 (human) Band 5q13.3 Start 76,403,285 bp End 76,708,132 bp
Gene location (Mouse) Chr. Chromosome 13 (mouse) Band 13 D1|13 50.26 cM Start 95,763,682 bp End 96,028,991 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa ventricular zone glomerulus metanephric glomerulus secondary oocyte liver right lobe of liver duodenum parotid gland monocyte Top expressed in ciliary body retinal pigment epithelium parotid gland iris left lobe of liver epithelium of stomach submandibular gland left colon jejunum lacrimal gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function Arp2/3 complex binding GTPase inhibitor activity actin filament binding actin binding phosphatidylinositol-3,4,5-trisphosphate binding calmodulin binding Cellular component cytoplasm filamentous actin cytosol filopodium microvillus cell surface actin cytoskeleton microtubule extracellular exosome lamellipodium plasma membrane secretory granule membrane Biological process thrombin-activated receptor signaling pathway regulation of GTPase activity Arp2/3 complex-mediated actin nucleation signal transduction negative regulation of GTPase activity neutrophil degranulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10788 544963 Ensembl ENSG00000145703 ENSMUSG00000021676 UniProt Q13576 Q3UQ44 RefSeq (mRNA) NM_001285460 NM_001285461 NM_001285462 NM_006633 NM_027711 RefSeq (protein) NP_001272389 NP_001272390 NP_001272391 NP_006624 NP_081987 Location (UCSC) Chr 5: 76.4 – 76.71 Mb Chr 13: 95.76 – 96.03 Mb PubMed search
Wikidata
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Function

This gene encodes a member of the IQGAP family. The protein contains three IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility.

Interactions

IQGAP2 has been shown to interact with CDC42 and RAC1.

Further reading

• McCallum SJ, Wu WJ, Cerione RA (1996). "Identification of a putative effector for Cdc42Hs with high sequence similarity to the RasGAP-related protein IQGAP1 and a Cdc42Hs binding partner with similarity to IQGAP2". J. Biol. Chem. 271 (36): 21732–7. doi:10.1074/jbc.271.36.21732. PMID 8702968.
• Yin H, Morioka H, Towle CA, Vidal M, Watanabe T, Weissbach L (2001). "Evidence that HAX-1 is an interleukin-1 alpha N-terminal binding protein". Cytokine. 15 (3): 122–37. doi:10.1006/cyto.2001.0891. PMID 11554782.
• Wennerberg K, Ellerbroek SM, Liu RY, Karnoub AE, Burridge K, Der CJ (2002). "RhoG signals in parallel with Rac1 and Cdc42". J. Biol. Chem. 277 (49): 47810–7. doi:10.1074/jbc.M203816200. PMID 12376551.
• Schmidt VA, Scudder L, Devoe CE, Bernards A, Cupit LD, Bahou WF (2003). "IQGAP2 functions as a GTP-dependent effector protein in thrombin-induced platelet cytoskeletal reorganization". Blood. 101 (8): 3021–8. doi:10.1182/blood-2002-09-2807. PMID 12515716.
• Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
• Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
• Chew CS, Okamoto CT, Chen X, Qin HY (2005). "IQGAPs are differentially expressed and regulated in polarized gastric epithelial cells". Am. J. Physiol. Gastrointest. Liver Physiol. 288 (2): G376-87. doi:10.1152/ajpgi.00290.2004. PMID 15458922.
• Wang H, Huo R, Xu M, Lu L, Xu Z, Li J, Zhou Z, Sha J (2005). "Cloning and characterization of a novel transcript variant of IQGAP2 in human testis". DNA Seq. 15 (5–6): 319–25. doi:10.1080/10425170400009012. PMID 15621655. S2CID 22014226.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.