Interleukin-1 receptor-associated kinase 3 is an enzyme that in humans is encoded by the IRAK3 gene.[5][6] Using in vivo liposome-mediated delivery of CRISPR/Cas9 plasmid expressing IRAK3 gRNA, IRAK3 was shown to be responsible for endotoxin-induced expression of A20 and VE-cadherin in endothelial cells. Thus, IRAK3 is crucial for maintenance and repair of endothelial barrier after endotoxin-induced lung injury.[7]

IRAK3
Identifiers
AliasesIRAK3, ASRT5, IRAKM, interleukin 1 receptor associated kinase 3
External IDsOMIM: 604459; MGI: 1921164; HomoloGene: 36215; GeneCards: IRAK3; OMA:IRAK3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_007199
NM_001142523

NM_028679
NM_001359184

RefSeq (protein)

NP_001135995
NP_009130

NP_082955
NP_001346113

Location (UCSC)Chr 12: 66.19 – 66.25 MbChr 10: 119.98 – 120.04 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000090376Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020227Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wesche H, Gao X, Li X, Kirschning CJ, Stark GR, Cao Z (July 1999). "IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family". The Journal of Biological Chemistry. 274 (27): 19403–10. doi:10.1074/jbc.274.27.19403. PMID 10383454.
  6. ^ "Entrez Gene: IRAK3 interleukin-1 receptor-associated kinase 3".
  7. ^ Soni D, Wang DM, Regmi SC, Mittal M, Vogel SM, Schlüter D, Tiruppathi C (May 2018). "Deubiquitinase function of A20 maintains and repairs endothelial barrier after lung vascular injury". Cell Death Discovery. 4 (60): 60. doi:10.1038/s41420-018-0056-3. PMC 5955943. PMID 29796309.

Further reading

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  • Overview of all the structural information available in the PDB for UniProt: Q9Y616 (Interleukin-1 receptor-associated kinase 3) at the PDBe-KB.