Iroquois-class homeodomain protein IRX-4 , also known as Iroquois homeobox protein 4 , is a protein that in humans is encoded by the IRX4 gene .[ 5] [ 6]
IRX4 is a member of the Iroquois homeobox gene family. Members of this family appear to play multiple roles during pattern formation of vertebrate embryos.[ 5]
^ a b c GRCh38: Ensembl release 89: ENSG00000113430 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021604 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ a b "Entrez Gene: iroquois homeobox 4" .
^ Bruneau BG, Bao ZZ, Tanaka M, Schott JJ, Izumo S, Cepko CL, Seidman JG, Seidman CE (January 2000). "Cardiac expression of the ventricle-specific homeobox gene Irx4 is modulated by Nkx2-5 and dHand" . Dev. Biol . 217 (2): 266–77. doi :10.1006/dbio.1999.9548 . PMID 10625552 .
Lewis MT, Ross S, Strickland PA, et al. (1999). "Regulated expression patterns of IRX-2, an Iroquois-class homeobox gene, in the human breast" . Cell Tissue Res . 296 (3): 549–54. doi :10.1007/s004410051316 . PMID 10370142 . S2CID 37046813 .
Wang GF, Nikovits W, Bao ZZ, Stockdale FE (2001). "Irx4 forms an inhibitory complex with the vitamin D and retinoic X receptors to regulate cardiac chamber-specific slow MyHC3 expression" . J. Biol. Chem . 276 (31): 28835–41. doi :10.1074/jbc.M103716200 . PMID 11382777 .
Bayrak F, Kömürcü-Bayrak E, Mutlu B, et al. (2008). "Genetic analysis of the Irx4 gene in hypertrophic cardiomyopathy". Turk Kardiyol Dern Ars . 36 (2): 90–5. PMID 18497553 .
Cirulli ET, Kasperavičiūtė D, Attix DK, et al. (2010). "Common genetic variation and performance on standardized cognitive tests" . European Journal of Human Genetics . 18 (7): 815–820. doi :10.1038/ejhg.2010.2 . PMC 2987367 . PMID 20125193 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .
This article incorporates text from the United States National Library of Medicine , which is in the public domain .