ISAC may refer to:

People

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  • Isac, variant spelling of Isaac (name)
  • Emil Isac (1886–1954), Romanian poet, dramatist, short story writer and critic
  • Isac Ludo (1894–1973), Romanian writer and political figure
  • Isac Peltz (1899–1980), Romanian prose writer and journalist

Other

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  • Vadul lui Isac is a village in Cahul District, Moldova
  • the Isac is a French river in the Loire-Atlantique department