Icometasone

Icometasone
Clinical data
Other names	Icomethasone; 9α-Chloro-11β,17α,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione
Drug class	Corticosteroid; Glucocorticoid
Identifiers
	IUPAC name (8S,9R,10S,11S,13S,14S,16R,17R)-9-Chloro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one;
CAS Number	4647-20-5;
PubChem CID	11407187;
ChemSpider	9582082;
UNII	2LP8SJ795G;
CompTox Dashboard (EPA)	DTXSID40196850 ;
Chemical and physical data
Formula	C22H29ClO5
Molar mass	408.92 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)CO)O)C)O)Cl)C;
	InChI InChI=1S/C22H29ClO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1; Key:NBMKJKDGKREAPL-CXSFZGCWSA-N;

Icometasone is a synthetic glucocorticoid corticosteroid which was never marketed.^[1]^[2]^[3]

References

^ Duchêne P, Giudicelli MD, Neau B, Gronfier A, Firmin Y, Villax P, et al. (April 1998). "Pharmacokinetics, protein binding and metabolic profile of 3H-icometasone enbutate following intravenous, oral and intratracheal administrations to Sprague-Dawley rats". Arzneimittel-Forschung. 48 (4): 371–378. PMID 9608879.
^ Negwer M, Scharnow HG (2001). Organic-chemical drugs and their synonyms: (an international survey). Wiley-VCH. p. 3730. ISBN 978-3-527-30247-5.
^ The use of stems in the selection of international Nonproprietary Names (INN) for pharmaceutical substances (PDF) (Report). World Health Organization. 2013. WHO/EMP/RHT/TSN/2013.1. Archived from the original (PDF) on 8 March 2022.

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