Ile may refer to:
- iLe, a Puerto Rican singer
- Ile District (disambiguation), multiple places
- Ilé-Ifẹ̀, an ancient Yoruba city in south-western Nigeria
- Interlingue (ISO 639:ile), a planned language
- Isoleucine, an amino acid abbreviated as Ile or I
- Another name for Ilargi, the moon in Basque mythology
- Historical spelling of Islay, Scottish island and girls' name
- Another name for the Ili River in eastern Kazakhstan
- Ile, a gender-neutral pronoun in Portuguese