Immediate early response 2

Immediate early response 2 is a protein that in humans is encoded by the IER2 gene.

IER2
Identifiers
Aliases	IER2, ETR101, immediate early response 2
External IDs	MGI: 104815; HomoloGene: 3607; GeneCards: IER2; OMA:IER2 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) Band 19p13.13 Start 13,150,411 bp End 13,154,911 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8 C3|8 41.02 cM Start 85,387,960 bp End 85,389,483 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in nipple skin of thigh trachea gastric mucosa human penis renal medulla saphenous vein granulocyte cardia vena cava Top expressed in granulocyte islet of Langerhans Ileal epithelium lacrimal gland hair follicle crypt of lieberkuhn of small intestine lip bone marrow right lung corneal stroma More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific Cellular component nucleoplasm cytoplasm nucleus Biological process neuron differentiation cell motility response to fibroblast growth factor transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9592 15936 Ensembl ENSG00000160888 ENSMUSG00000053560 UniProt Q9BTL4 P17950 RefSeq (mRNA) NM_004907 NM_010499 RefSeq (protein) NP_004898 NP_004898.2 NP_034629 Location (UCSC) Chr 19: 13.15 – 13.15 Mb Chr 8: 85.39 – 85.39 Mb PubMed search
Wikidata
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Further reading

• Takaya T, Kasatani K, Noguchi S, Nikawa J (July 2009). "Functional analyses of immediate early gene ETR101 expressed in yeast". Biosci. Biotechnol. Biochem. 73 (7): 1653–60. doi:10.1271/bbb.90162. PMID 19584537. S2CID 26368630.
• Neeb A, Wallbaum S, Novac N, Dukovic-Schulze S, Scholl I, Schreiber C, Schlag P, Moll J, Stein U, Sleeman JP (August 2012). "The immediate early gene Ier2 promotes tumor cell motility and metastasis, and predicts poor survival of colorectal cancer patients". Oncogene. 31 (33): 3796–806. doi:10.1038/onc.2011.535. PMID 22120713.
• Wu W, Zhang X, Lv H, Liao Y, Zhang W, Cheng H, Deng Z, Shen J, Yuan Q, Zhang Y, Shen W (October 2015). "Identification of immediate early response protein 2 as a regulator of angiogenesis through the modulation of endothelial cell motility and adhesion". Int. J. Mol. Med. 36 (4): 1104–10. doi:10.3892/ijmm.2015.2310. PMID 26260137.