Indolepyruvate decarboxylase

The enzyme indolepyruvate decarboxylase (EC 4.1.1.74) catalyzes the chemical reaction

indolepyruvate decarboxylase
Identifiers
EC no.4.1.1.74
CAS no.9074-92-4
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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PMCarticles
PubMedarticles
NCBIproteins
3-(indol-3-yl)pyruvate 2-(indol-3-yl)acetaldehyde + CO2

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 3-(indol-3-yl)pyruvate carboxy-lyase [(2-indol-3-yl)acetaldehyde-forming]. Other names in common use include indol-3-yl-pyruvate carboxy-lyase, and 3-(indol-3-yl)pyruvate carboxy-lyase. This enzyme participates in tryptophan metabolism.

Structural studies

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As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1OVM.

References

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  • Koga J (May 1995). "Structure and function of indolepyruvate decarboxylase, a key enzyme in indole-3-acetic acid biosynthesis". Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1249 (1): 1–13. doi:10.1016/0167-4838(95)00011-I. PMID 7766676.