The enzyme indolepyruvate decarboxylase (EC 4.1.1.74) catalyzes the chemical reaction
| indolepyruvate decarboxylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 4.1.1.74 | ||||||||
| CAS no. | 9074-92-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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- 3-(indol-3-yl)pyruvate 2-(indol-3-yl)acetaldehyde + CO2
This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 3-(indol-3-yl)pyruvate carboxy-lyase [(2-indol-3-yl)acetaldehyde-forming]. Other names in common use include indol-3-yl-pyruvate carboxy-lyase, and 3-(indol-3-yl)pyruvate carboxy-lyase. This enzyme participates in tryptophan metabolism.
Structural studies
editAs of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1OVM.
References
edit- Koga J (May 1995). "Structure and function of indolepyruvate decarboxylase, a key enzyme in indole-3-acetic acid biosynthesis". Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1249 (1): 1–13. doi:10.1016/0167-4838(95)00011-I. PMID 7766676.
