Inositol-1,4-bisphosphate 1-phosphatase

The enzyme inositol-1,4-bisphosphate 1-phosphatase (EC 3.1.3.57) catalyzes the reaction

inositol-1,4-bisphosphate 1-phosphatase
Identifiers
EC no.3.1.3.57
CAS no.111070-17-8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins
1D-myo-inositol 1,4-bisphosphate + H2O 1D-myo-inositol 4-phosphate + phosphate

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name is D-myo-inositol-1,4-bisphosphate 1-phosphohydrolase. This enzyme is also called inositol-polyphosphate 1-phosphatase. This enzyme participates in inositol phosphate metabolism and phosphatidylinositol signaling system.

Structural studies

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As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1INP and 1JP4.

References

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  • Berridge MJ, Dawson RM, Downes CP, Heslop JP, Irvine RF (1983). "Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides". Biochem. J. 212 (2): 473–82. doi:10.1042/bj2120473. PMC 1152070. PMID 6309146.
  • Connolly TM, Bansal VS, Bross TE, Irvine RF, Majerus PW (1987). "The metabolism of tris- and tetraphosphates of inositol by 5-phosphomonoesterase and 3-kinase enzymes". J. Biol. Chem. 262 (5): 2146–9. doi:10.1016/S0021-9258(18)61629-1. PMID 3029066.
  • Inhorn RC, Majerus PW (1987). "Inositol polyphosphate 1-phosphatase from calf brain. Purification and inhibition by Li+, Ca2+, and Mn2+". J. Biol. Chem. 262 (33): 15946–52. doi:10.1016/S0021-9258(18)47680-6. PMID 2824473.