Inositol-polyphosphate multikinase (EC 2.7.1.151, IpK2, IP3/IP4 6-/3-kinase, IP3/IP4 dual-specificity 6-/3-kinase, IpmK, ArgRIII, AtIpk2alpha, AtIpk2beta, inositol polyphosphate 6-/3-/5-kinase) is an enzyme with systematic name ATP:1D-myo-inositol-1,4,5-trisphosphate 6-phosphotransferase.[1][2][3][4] This enzyme catalyses the following chemical reaction
| Inositol-polyphosphate multikinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.7.1.151 | ||||||||
| CAS no. | 9077-69-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- 2 ATP + 1D-myo-inositol 1,4,5-trisphosphate 2 ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate (overall reaction)
- (1a) ATP + 1D-myo-inositol 1,4,5-trisphosphate ADP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate
- (1b) ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
This enzyme also phosphorylates Ins(1,4,5)P3 to Ins(1,3,4,5)P4, Ins(1,3,4,5)P4 to Ins(1,3,4,5,6)P5, and Ins(1,3,4,5,6)P4 to Ins(PP)P4, isomer unknown.
References
edit- ^ Saiardi A, Erdjument-Bromage H, Snowman AM, Tempst P, Snyder SH (November 1999). "Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases". Current Biology. 9 (22): 1323–6. doi:10.1016/S0960-9822(00)80055-X. PMID 10574768.
- ^ Odom AR, Stahlberg A, Wente SR, York JD (March 2000). "A role for nuclear inositol 1,4,5-trisphosphate kinase in transcriptional control". Science. 287 (5460): 2026–9. doi:10.1126/science.287.5460.2026. PMID 10720331.
- ^ Stevenson-Paulik J, Odom AR, York JD (November 2002). "Molecular and biochemical characterization of two plant inositol polyphosphate 6-/3-/5-kinases". The Journal of Biological Chemistry. 277 (45): 42711–8. doi:10.1074/jbc.M209112200. PMID 12226109.
- ^ Verbsky JW, Chang SC, Wilson MP, Mochizuki Y, Majerus PW (January 2005). "The pathway for the production of inositol hexakisphosphate in human cells". The Journal of Biological Chemistry. 280 (3): 1911–20. doi:10.1074/jbc.M411528200. PMID 15531582.
