Integrin alpha D

Integrin alpha-D is a protein that in humans is encoded by the ITGAD gene.

ITGAD
Identifiers
Aliases	ITGAD, ADB2, CD11D, integrin subunit alpha D
External IDs	OMIM: 602453; MGI: 3578624; HomoloGene: 56919; GeneCards: ITGAD; OMA:ITGAD - orthologs
Gene location (Human) Chr. Chromosome 16 (human) Band 16p11.2 Start 31,393,335 bp End 31,426,505 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 F3 Start 127,753,548 bp End 127,822,988 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte spleen gastrocnemius muscle lymph node muscle of thigh appendix blood decidua right lobe of liver gallbladder Top expressed in spleen spermatid testicle spermatocyte islet of Langerhans bone marrow embryo granulocyte thymus primary oocyte More reference expression data BioGPS n/a
Gene ontology Molecular function metal ion binding protein heterodimerization activity Cellular component integral component of membrane cell surface integrin complex plasma membrane membrane Biological process integrin-mediated signaling pathway heterotypic cell-cell adhesion extracellular matrix organization cell adhesion immune response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3681 381924 Ensembl ENSG00000156886 ENSMUSG00000070369 UniProt Q13349 Q3V0T4 RefSeq (mRNA) NM_005353 NM_001318185 NM_001029872 NM_001177632 RefSeq (protein) NP_001305114 NP_005344 NP_001025043 Location (UCSC) Chr 16: 31.39 – 31.43 Mb Chr 7: 127.75 – 127.82 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Van der Vieren M, Le Trong H, Wood CL, et al. (1996). "A novel leukointegrin, alpha d beta 2, binds preferentially to ICAM-3". Immunity. 3 (6): 683–90. doi:10.1016/1074-7613(95)90058-6. PMID 8777714.
• Grayson MH, Van der Vieren M, Sterbinsky SA, et al. (1999). "alphadbeta2 integrin is expressed on human eosinophils and functions as an alternative ligand for vascular cell adhesion molecule 1 (VCAM-1)". J. Exp. Med. 188 (11): 2187–91. doi:10.1084/jem.188.11.2187. PMC 2212388. PMID 9841932.
• Van der Vieren M, Crowe DT, Hoekstra D, et al. (1999). "The leukocyte integrin alpha D beta 2 binds VCAM-1: evidence for a binding interface between I domain and VCAM-1". J. Immunol. 163 (4): 1984–90. doi:10.4049/jimmunol.163.4.1984. PMID 10438935.
• Noti JD, Johnson AK, Dillon JD (2000). "Structural and functional characterization of the leukocyte integrin gene CD11d. Essential role of Sp1 and Sp3". J. Biol. Chem. 275 (12): 8959–69. doi:10.1074/jbc.275.12.8959. PMID 10722744.
• Noti JD (2003). "Expression of the myeloid-specific leukocyte integrin gene CD11d during macrophage foam cell differentiation and exposure to lipoproteins". Int. J. Mol. Med. 10 (6): 721–7. doi:10.3892/ijmm.10.6.721. PMID 12429998.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Noti JD, Johnson AK, Dillon JD (2005). "The leukocyte integrin gene CD11d is repressed by gut-enriched Kruppel-like factor 4 in myeloid cells". J. Biol. Chem. 280 (5): 3449–57. doi:10.1074/jbc.M412627200. PMID 15561714.

External links

• ITGAD Info with links in the Cell Migration Gateway Archived 2014-12-11 at the Wayback Machine