Interleukin-9 receptor

Interleukin 9 receptor (IL9R) also known as CD129 (Cluster of Differentiation 129) is a type I cytokine receptor. IL9R also denotes its human gene.[5]

IL9R
Identifiers
AliasesIL9R, CD129, IL-9R, interleukin 9 receptor
External IDsOMIM: 300007; MGI: 96564; HomoloGene: 37591; GeneCards: IL9R; OMA:IL9R - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002186
NM_176786

NM_001134458
NM_008374

RefSeq (protein)

NP_002177
NP_789743

NP_001127930
NP_032400

Location (UCSC)Chr X: 156 – 156.01 MbChr 11: 32.14 – 32.15 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a cytokine receptor that specifically mediates the biological effects of interleukin 9 (IL9). The functional IL9 receptor complex requires this protein as well as the interleukin 2 receptor, gamma (IL2RG), a common gamma subunit shared by the receptors of many different cytokines. The ligand binding of this receptor leads to the activation of various JAK kinases and STAT proteins, which connect to different biologic responses.  This gene is located at the pseudoautosomal regions of X and Y chromosomes. Genetic studies suggested an association of this gene with the development of asthma. Multiple pseudogenes on chromosome 9, 10, 16, and 18 have been described. Alternatively spliced transcript variants encoding distinct isoforms have been reported.[5]

Interactions

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Interleukin-9 receptor has been shown to interact with YWHAZ.[6]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000124334Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020279Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: IL9R interleukin 9 receptor".
  6. ^ Sliva, D; Gu M; Zhu Y X; Chen J; Tsai S; Du X; Yang Y C (February 2000). "14-3-3zeta interacts with the alpha-chain of human interleukin 9 receptor". Biochem. J. 345 (3): 741–7. doi:10.1042/0264-6021:3450741. ISSN 0264-6021. PMC 1220812. PMID 10642536.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.