Interleukin-1 receptor (IL-1R) is a cytokine receptor which binds interleukin 1.[1] Two forms of the receptor exist. The type I receptor is primarily responsible for transmitting the inflammatory effects of interleukin-1 (IL-1) while type II receptors may act as a suppressor of IL-1 activity by competing for IL-1 binding.[1] Also opposing the effects of IL-1 is the IL-1 receptor antagonist (IL-1RA).[2]
| interleukin 1 receptor, type I | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | IL1R1 | ||||||
| Alt. symbols | IL1R, IL1RA | ||||||
| NCBI gene | 3554 | ||||||
| HGNC | 5993 | ||||||
| OMIM | 147810 | ||||||
| RefSeq | NM_000877 | ||||||
| UniProt | P14778 | ||||||
| Other data | |||||||
| Locus | Chr. 2 q12 | ||||||
| |||||||
| interleukin 1 receptor, type II | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | IL1R2 | ||||||
| Alt. symbols | IL1RB | ||||||
| NCBI gene | 7850 | ||||||
| HGNC | 5994 | ||||||
| OMIM | 147811 | ||||||
| RefSeq | NM_173343 | ||||||
| UniProt | P27930 | ||||||
| Other data | |||||||
| Locus | Chr. 2 q12 | ||||||
| |||||||
| interleukin 1 receptor accessory protein | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | IL1RAP | ||||||
| Alt. symbols | IL-1RAcP, IL1R3, C3orf13 | ||||||
| NCBI gene | 3556 | ||||||
| HGNC | 5995 | ||||||
| OMIM | 602626 | ||||||
| RefSeq | NM_134470 | ||||||
| UniProt | Q9NPH3 | ||||||
| Other data | |||||||
| Locus | Chr. 3 q28 | ||||||
| |||||||
The IL-1 receptor accessory protein (IL1RAP) is a transmembrane protein that interacts with IL-1R and is required for IL-1 signal transduction.[3]
References
edit- ^ a b Kuno K, Matsushima K (1994). "The IL-1 receptor signaling pathway". J. Leukoc. Biol. 56 (5): 542–7. doi:10.1002/jlb.56.5.542. PMID 7964161. S2CID 43095473. Archived from the original (abstract page) on 2005-05-07. Retrieved 2008-02-28.
- ^ Arend WP (1991). "Interleukin 1 receptor antagonist. A new member of the interleukin 1 family". J. Clin. Invest. 88 (5): 1445–51. doi:10.1172/JCI115453. PMC 295645. PMID 1834696.
- ^ Wesche H, Korherr C, Kracht M, Falk W, Resch K, Martin MU (March 1997). "The interleukin-1 receptor accessory protein (IL-1RAcP) is essential for IL-1-induced activation of interleukin-1 receptor-associated kinase (IRAK) and stress-activated protein kinases (SAP kinases)". J. Biol. Chem. 272 (12): 7727–31. doi:10.1074/jbc.272.12.7727. PMID 9065432.
External links
edit- Receptors,+Interleukin-1 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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