An inverse vaccine, or reverse vaccine, is a hypothetical approach to the use of vaccines that trains the immune system to not respond to certain substances. Under laboratory conditions, an inverse vaccine has been shown to combat autoimmune diseases.[1] An autoimmune disease attacks the body's own cells and substances, an inverse vaccine must counteract this. The current method of combating the effects of an autoimmune disease is to suppress the entire immune system, which means that infections cannot be fought.
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Approaches
editAs of 2010, human trials were underway using naked DNA that encoded specific antigens of interests, particularly for multiple sclerosis using BHT-3009, and type 1 diabetes mellitus.[2]
Possible applications
editPossible applications of inverse vaccines include:[3]
- Multiple Sclerosis (MS)
- Type 1 diabetes
- Coeliac disease
- Allergic asthma
- Food allergies[4]
- Chronic inflammatory diseases, such as Crohn's disease
- Preventing an immune response after an organ transplant
- Rheumatoid arthritis[5]
As of 2024, a study is underway into the safety of an inverse vaccine against multiple sclerosis, with a small group of patients and volunteers; for an inverse vaccine against celiac disease, a safety and efficacy study is underway in a limited group of subjects.[3][6][7]
See also
edit- Allergen immunotherapy, an analogous technique for the treatment of allergy
References
edit- ^
Sarah C.P. Williams (2023-09-11). ""Inverse vaccine" shows potential to treat multiple sclerosis and other autoimmune diseases". The University of Chicago. Archived from the original on 2023-12-03. Retrieved 2023-12-04.
A new type of vaccine developed by researchers at the University of Chicago's Pritzker School of Molecular Engineering (PME) has shown in the lab setting that it can completely reverse autoimmune diseases like multiple sclerosis and type 1 diabetes — all without shutting down the rest of the immune system.
- ^ Steinman, L. (May 2010). "Inverse vaccination, the opposite of Jenner's concept, for therapy of autoimmunity". Journal of Internal Medicine. 267 (5): 441–451. doi:10.1111/j.1365-2796.2010.02224.x. PMID 20433574.
- ^ a b
"Autoimmune Diseases and the Promise of Inverse Vaccines". CivilsDaily. 2023-10-02. Archived from the original on 2023-10-10. Retrieved 2023-12-04.
In the quest to combat autoimmune diseases, scientists are exploring a groundbreaking approach: inverse vaccines. While still in the developmental stage and yet to be tested on humans, this novel concept holds the potential to revolutionize the treatment of autoimmune diseases.
- ^
Dr. Jeffrey A. Hubbell; Dr. Cathryn R. Nagler (2023-07-10). "Inverse Food Allergy Vaccines Through Targeted Antigen Delivery — Food Allergy Fund". Food Allergy Fund. Archived from the original on 2023-12-04. Retrieved 2023-12-04.
Researchers know that something called "food antigens" create tolerance for specific food proteins. Now researchers want to create an inverse vaccine that puts those particular food antigens to work inside of food allergic individuals so they can tolerate their allergens.
- ^ Thumsi, Abhirami; Martínez, Diego; Swaminathan, Srivatsan J.; Esrafili, Arezoo; Suresh, Abhirami P.; Jaggarapu, Madhan Mohan Chandrasekhar; Lintecum, Kelly; Halim, Michelle; Mantri, Shivani V.; Sleiman, Yasmine; Appel, Nicole; Gu, Haiwei; Curtis, Marion; Zuniga, Cristal; Acharya, Abhinav P. (19 March 2024). "Inverse-Vaccines for Rheumatoid Arthritis Re-establish Metabolic and Immunological Homeostasis in Joint Tissues". Advanced Healthcare Materials. doi:10.1002/adhm.202303995.
- ^ "Pipeline – Anokion". Anokion SA. Archived from the original on 2024-02-18. Retrieved 2024-02-18.
- ^
"A Study of Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of KAN-101 in Celiac Disease (ACeD-it)". National Center for Biotechnology Information. 2024-01-16. Archived from the original on 2024-02-18. Retrieved 2024-02-18.
This study is to evaluate the Pharmacodynamic (PD), safety, tolerability, Pharmacokinetic (PK), and plasma biomarker response of KAN-101 in participants with Celiac Disease (CeD).