Irala is a surname of Basque origin.[1] Notable people with the surname include:
- Adriano Irala (1894-1933), Paraguayan professor and journalist
- Blas Irala (born 1983), Paraguayan footballer
- Casimiro Abdon Irala Arguello (born 1936), Brazilian Jesuit priest and musician
- Domingo Martínez de Irala (1509-1556), Spanish conquistador
- Pedro Richard Irala (born 1979), Paraguayan footballer
- Severiano Irala (died 2012), Paraguayan footballer