JNJ-28330835

JNJ-28330835
Clinical data
Other names	JNJ28330835
Drug class	Selective androgen receptor modulator
Legal status
Legal status	US: Investigational drug;
Identifiers
	IUPAC name (S)-N-(4-cyano-3-(trifluoromethyl)phenyl)-5-methyl-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazole-5-carboxamide;
CAS Number	888072-47-7 ;
PubChem CID	11703306;
DrugBank	DB13936;
UNII	544SF265DA;
CompTox Dashboard (EPA)	DTXSID201336525 ;
Chemical and physical data
Formula	C14H10F6N4O
Molar mass	364.251 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C([C@@]1(C)NN=C(C(F)(F)F)C1)NC2=CC=C(C#N)C(C(F)(F)F)=C2;
	InChI InChI=1S/C14H10F6N4O/c1-12(5-10(23-24-12)14(18,19)20)11(25)22-8-3-2-7(6-21)9(4-8)13(15,16)17/h2-4,24H,5H2,1H3,(H,22,25)/t12-/m0/s1; Key:RYBKPGYFXRNMMU-LBPRGKRZSA-N;

JNJ-28330835 is a drug which acts as a selective androgen receptor modulator (SARM).^[1] In studies on rats it was found to enhance muscle growth and sexual behavior but with minimal effects on prostate gland size. A number of related compounds are known, though JNJ-28330835 has progressed furthest through development.^[2]^[3]

References

^ "Delving into the Latest Updates on JNJ-28330835 with Synapse". Synapse. 20 September 2024. Retrieved 22 October 2024.
^ Zhang X, Li X, Allan GF, Sbriscia T, Linton O, Lundeen SG, Sui Z (January 2007). "Serendipitous discovery of novel imidazolopyrazole scaffold as selective androgen receptor modulators". Bioorganic & Medicinal Chemistry Letters. 17 (2): 439–43. doi:10.1016/j.bmcl.2006.10.035. PMID 17079140.
^ Allan GF, Tannenbaum P, Sbriscia T, Linton O, Lai MT, Haynes-Johnson D, et al. (August 2007). "A selective androgen receptor modulator with minimal prostate hypertrophic activity enhances lean body mass in male rats and stimulates sexual behavior in female rats". Endocrine. 32 (1): 41–51. doi:10.1007/s12020-007-9005-2. PMID 17992601. S2CID 21846285.

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[Synapse-1] "Delving into the Latest Updates on JNJ-28330835 with Synapse". Synapse. 20 September 2024. Retrieved 22 October 2024.

[pmid17079140-2] Zhang X, Li X, Allan GF, Sbriscia T, Linton O, Lundeen SG, Sui Z (January 2007). "Serendipitous discovery of novel imidazolopyrazole scaffold as selective androgen receptor modulators". Bioorganic & Medicinal Chemistry Letters. 17 (2): 439–43. doi:10.1016/j.bmcl.2006.10.035. PMID 17079140.

[pmid17992601-3] Allan GF, Tannenbaum P, Sbriscia T, Linton O, Lai MT, Haynes-Johnson D, et al. (August 2007). "A selective androgen receptor modulator with minimal prostate hypertrophic activity enhances lean body mass in male rats and stimulates sexual behavior in female rats". Endocrine. 32 (1): 41–51. doi:10.1007/s12020-007-9005-2. PMID 17992601. S2CID 21846285.

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[2]

[3]

JNJ-28330835

See also

References