JWH-370

JWH-370
Legal status
Legal status	CA: Schedule II; UK: Class B;
Identifiers
	IUPAC name [5-(2-methylphenyl)-1-pentylpyrrol-3-yl]-naphthalen-1-ylmethanone;
CAS Number	914458-22-3 ;
PubChem CID	44418312;
ChemSpider	23277889 ;
UNII	HJZ9JN4HNM;
CompTox Dashboard (EPA)	DTXSID701016340 ;
Chemical and physical data
Formula	C27H27NO
Molar mass	381.519 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCCCCN1C=C(C=C1C2=CC=CC=C2C)C(=O)C3=CC=CC4=CC=CC=C43;
	InChI InChI=1S/C27H27NO/c1-3-4-9-17-28-19-22(18-26(28)23-14-7-5-11-20(23)2)27(29)25-16-10-13-21-12-6-8-15-24(21)25/h5-8,10-16,18-19H,3-4,9,17H2,1-2H3 ; Key:HZMLAMXVETUEJZ-UHFFFAOYSA-N ;

JWH-370 ([5-(2-methylphenyl)-1-pentylpyrrol-3-yl]-naphthalen-1-ylmethanone) is a synthetic cannabinoid from the naphthoylpyrrole family which acts as an agonist of the CB₁ (K_i = 5.6 ± 0.4nM) and CB₂ (K_i = 4.0 ± 0.5nM) receptors, with a slight selectivity for the CB₂ receptor. JWH-370 was first synthesized in 2006 by John W. Huffman and colleagues to examine the nature of ligand binding to the CB₁ receptor.^[1]

Legality

In the United States JWH-370 is not federally scheduled, although some states have passed legislation banning the sale, possession, and manufacture of JWH-370.^[2]^[3]^[4]^[5]

In Canada, JWH-370 and other naphthoylpyrrole-based cannabinoids are Schedule II controlled substances under the Controlled Drugs and Substances Act.^{[citation needed]}

In the United Kingdom, JWH-370 and other naphthoylpyrrole-based cannabinoids are considered Class B drugs under the Misuse of Drugs Act 1971.^{[citation needed]}

References

^ Huffman JW, Padgett LW, Isherwood ML, Wiley JL, Martin BR (October 2006). "1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors". Bioorganic & Medicinal Chemistry Letters. 16 (20): 5432–5. doi:10.1016/j.bmcl.2006.07.051. PMID 16889960.
^ 21 U.S.C. § 812: Schedules of controlled substances
^ "The 2020 Florida Statutes". www.leg.state.fl.us. Retrieved 20 August 2021.
^ "Arizona Revised Statutes Title 13. Criminal Code § 13-3401". www.azleg.gov. Retrieved 20 August 2021.
^ "California Code, Health and Safety Code - HSC § 11357.5". Findlaw.

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[1] Huffman JW, Padgett LW, Isherwood ML, Wiley JL, Martin BR (October 2006). "1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors". Bioorganic & Medicinal Chemistry Letters. 16 (20): 5432–5. doi:10.1016/j.bmcl.2006.07.051. PMID 16889960.

[2] 21 U.S.C. § 812: Schedules of controlled substances

[3] "The 2020 Florida Statutes". www.leg.state.fl.us. Retrieved 20 August 2021.

[4] "Arizona Revised Statutes Title 13. Criminal Code § 13-3401". www.azleg.gov. Retrieved 20 August 2021.

[5] "California Code, Health and Safety Code - HSC § 11357.5". Findlaw.

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Legal status

Legal status	CA: Schedule II UK: Class B
Identifiers
IUPAC name [5-(2-methylphenyl)-1-pentylpyrrol-3-yl]-naphthalen-1-ylmethanone
CAS Number	914458-22-3^Y
PubChem CID	44418312
ChemSpider	23277889^Y
UNII	HJZ9JN4HNM
CompTox Dashboard (EPA)	DTXSID701016340
Chemical and physical data
Formula	C₂₇H₂₇NO
Molar mass	381.519 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CCCCCN1C=C(C=C1C2=CC=CC=C2C)C(=O)C3=CC=CC4=CC=CC=C43
InChI InChI=1S/C27H27NO/c1-3-4-9-17-28-19-22(18-26(28)23-14-7-5-11-20(23)2)27(29)25-16-10-13-21-12-6-8-15-24(21)25/h5-8,10-16,18-19H,3-4,9,17H2,1-2H3^Y Key:HZMLAMXVETUEJZ-UHFFFAOYSA-N^Y

JWH-370

Legality

See also

References