Jacome or Jácome is a Portuguese and Spanish surname and a given name. Notable people with the name include:
- Jácome de Bruges (1418–unknown), Flemish businessman
- Jácome Crombergeres (c. 1525 – c. 1560), spanish printer
- Jacome Gonsalves (1676–1742), Sri Lankan priest and missionary
- Jácome Ratton (1736–1820), Franco-Portuguese businessman
- Antía Jácome (born 1999), Spanish sprint canoeist
- Antônio Jácome (born 1962), Brazilian politician
- Arella Jácome (born 2004), Ecuadorian politician
- Dionisio Pérez-Jácome Friscione (born 1967), Mexican economist
- Dolores Isabel Jacome Silva (born 1991), Portuguese footballer
- Elías Jácome (1945–1999), Ecuadorian football referee
- Fernando Jácome (born 1980), Colombian freestyle swimmer
- Jason Jacome (born 1970), American baseball pitcher
- Juan Jácome (born 1960), Ecuadorian footballer
- Leon Jacome, an alias of Ramón Mercader (1913–1978), Spanish communist and Soviet spy
- Mariela Jácome (born 1996), American-born Ecuadorian footballer
- Rafael Jácome de Andrade (1851–1900), Portuguese military figure and politician
- Santiago Jácome (born 1973), Ecuadorian footballer
- Tomasa Yarhui Jacomé (born 1968), Bolivian lawyer and politician
This page or section lists people that share the same given name or the same family name.
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