Jakšić (Serbian Cyrillic: Јакшић, pronounced [jǎkʃitɕ]) is a South Slavic surname. It may refer to:
- Jakšić noble family
- a family of the Drobnjaci clan
- Đura Jakšić, Serbian artist
- Đurađ Jakšić, Serbian politician
- Jovana Jakšić, Serbian tennis player
- Marko Jakšić (footballer, born 1983), Serbian footballer
- Marko Jakšić (footballer, born 1987), Serbian footballer
- Milovan Jakšić, Yugoslav footballer
- Nenad Jakšić, Serbian footballer
- Nikola Jakšić, Serbian water polo player