James Caine (1908–1971) was an English professional footballer.
James Caine may also refer to:
- Jim Caine (jazz pianist) (1926–2018), Manx jazz pianist, radio presenter and raconteur
- James Caine, candidate in South Tyneside Council election, 2004
James Caine (1908–1971) was an English professional footballer.
James Caine may also refer to: