James Duane (1733–1797) was a member of the Continental Congress and mayor of New York City.
James Duane may also refer to:
- James Duane (fireboat), a fireboat of New York City named after the mayor
- James Duane (professor) (born 1959), American lawyer
- James Chatham Duane (1824–1897), engineering officer in the Union Army during the American Civil War
See also
edit- James Duane Doty (1799–1865), land speculator and politician