James Simms may refer to:
- James Simms (instrument maker) (1828–1915), British instrument maker
- James Simms (Newfoundland official) (1779–1863), lawyer and merchant in Newfoundland
- James M. Simms (1823–?), African-American minister, newspaper publisher and member of the Georgia Assembly
- James P. Simms (1837–1887), Confederate States Army general and member of the Georgia legislature
This disambiguation page lists articles about people with the same name.
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