Jane Ying Wu (Chinese: 吴瑛; 1963 – July 10, 2024) was a Chinese American neuroscientist who served as the Charles Louis Mix Professor of Neurology at the Feinberg School of Medicine of Northwestern University. Wu died by suicide at her home in Chicago in 2024 after the forced closure of her laboratory at Northwestern University, a place she served as professor for nearly two decades. She graduated from Stanford University School of Medicine with a Doctor of Philosophy degree in 1991. Her research area was in the field of post-transcriptional gene regulation and its involvement in human pathogenesis.
Jane Ying Wu | |
|---|---|
吴瑛 | |
 | |
| Born | 1963 |
| Died | July 10, 2024 |
| Alma mater | Shanghai Medical University (BMed) Stanford University (PhD) |
| Spouse | Rao Yi |
| Scientific career | |
| Fields | Neurology |
| Institutions | Stanford University Harvard University Washington University in St. Louis Northwestern University |
| Thesis | Molecular studies of Hapatitis B virus (1991) |
| Doctoral advisor | William S. Robinson |
| Website | Faculty page (archived) Wu Lab page (archived) |
Early life and education
editBorn in 1963 in Hefei, Anhui, China.[1] She lived with her grandmother while her parents were in a labor camp.[2]
Wu attended Shanghai Medical University for undergraduate studies and graduated with a Bachelor of Medicine in 1986.[1][3] She traveled to the United States for graduate studies and received a Doctor of Philosophy in cancer biology from Stanford University School of Medicine in 1991.[1] Her doctoral dissertation was titled, Molecular Studies of Hepatitis B Virus.[2] Her doctoral advisor was William S. Robinson.[2] She dedicated her dissertation to the martyrs[clarification needed] of the 1989 Tiananmen Square protests and massacre.[2][failed verification] After receiving her doctorate, Wu conducted postdoctoral research at Harvard University.[1]
Career
editWu spent ten years at Washington University in St. Louis, where she served as an assistant professor and then as an associate professor in pediatrics, molecular biology, and pharmacology.[1]
In 2005, Wu joined Northwestern University where her research concentrated on two closely related biological processes, RNA splicing and the role of regulatory RNA-binding proteins.[1] She led a neurology and genetics laboratory at the Feinberg School of Medicine.[1] By 2007, she was the Charles Louis Mix Professor of Neurology at Northwestern University Feinberg School of Medicine.[4] The same year, she was elected to the American Society for Clinical Investigation.[4]
In 2009, Wu was invited "by the Chinese government under the Thousand Talents Programme to help run a lab and train students" at the Institute of Biophysics, Chinese Academy of Sciences.[1]
Research
editHer research interests centered on post-transcriptional gene regulation and its involvement in human diseases.[4] She focused on pre-mRNA splicing, a crucial process in eukaryotic gene expression that played a significant role in genetic diversity.[4] Defects in pre-mRNA splicing were linked to the development of numerous human disorders.[4] Wu's research team investigated the mechanisms that regulated pre-mRNA splicing and alternative splicing in genes essential for cell death and neuronal function.[4] They specifically examined how splicing defects contributed to neurodegenerative diseases such as frontotemporal dementia and retinal degeneration.[4] Additionally, Wu explored the fundamental processes involved in tumor development and metastasis.[4] Her discovery of how a neuronal migration signal modulated chemokine activity provided new insights into chemokine regulation, uncovering a conserved mechanism that controlled cell migration across various cell types.[4] Her lab also studied the role of neuronal guidance cues in tumor metastasis and developed new approaches to address inflammatory diseases.[4]
Personal life
editWu met her husband Rao Yi at Shanghai Medical University, where Wu was an undergraduate medical student (graduated in 1986) and Rao was a master's student (dropped out in 1985).[5][2][6]
Death
editAfter Wu's lab was shut down by Northwestern University, Wu died by suicide at her home in Chicago, Illinois, on July 10, 2024.[1] After nearly two decades professorship at Northwestern University, all of her web pages at Northwestern University were immediately removed by Northwestern University, with no obituary issued by the university. Researchers from multiple universities and leaders of social organizations were shocked by the incident. The South China Morning Post stated that the China Initiative by the United States federal government was related to the forced closure of her laboratory.[1]
References
edit- ^ a b c d e f g h i j Xin, Ling (2024-08-31). "Exclusive | China-born neuroscientist Jane Wu lost her US lab. Then she lost her life". South China Morning Post. Archived from the original on 2024-09-03. Retrieved 2024-09-03.
- ^ a b c d e Wu, Jane Ying (1991). Molecular Studies of Hepatitis B Virus (Ph.D. thesis). Stanford University. OCLC 79699485.
- ^ "美国西北大学教授吴瑛自杀离世，生前遭到NIH调查，被赶出实验室 | 新闻频道 | 领研网". www.linkresearcher.com. Archived from the original on 2024-09-26. Retrieved 2024-09-26.
- ^ a b c d e f g h i j "Home". The American Society for Clinical Investigation. Archived from the original on 2024-09-03. Retrieved 2024-09-03.
- ^ Madish, Caroline (2024-07-31). "Jane Wu Northwestern Death, Professor Rao Yi's ex-wife and Northwestern University Professor Dr. Jane Ying Wu died by suicide - earlymemorialobits.com". Archived from the original on 2024-09-04. Retrieved 2024-09-04.
- ^ "饶毅1983年发表的中文学术杂志综述-2021-深圳湾实验室分子生理学研究所". 深圳湾实验室分子生理学研究所 Institute of Molecular Physiology of Shenzhen Bay Laboratory. Archived from the original on 2024-09-26. Retrieved 2024-09-26.