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Pankaj "Jay" Pasricha is a physician and researcher specializing in gastroenterology and neurogastroenterology. He currently serves as the chair of medicine at the Mayo Clinic in Scottsdale, Arizona. Formerly, he served as the director of the Johns Hopkins Center for Neurogastroenterology and was the founder and co-director of the Amos Food, Body and Mind Center, Vice Chair of Medicine for Innovation and Commercialization in the Johns Hopkins School of Medicine, and Professor of Innovation Management at the Carey Business School.
Jay Pasricha | |
|---|---|
 | |
| Alma mater | All-India Institute of Medical Sciences |
| Known for | Leadership in gastroenterology, endoscopic procedures and devices, and GI motility disorders research |
| Spouse | Reena Pasricha |
| Children | 3 |
| Awards | American Gastroenterological Association Master’s Award for Outstanding Sustained Achievement in Gastroenterology, Nobility in Science Award from the National Pancreas Foundation |
| Scientific career | |
| Fields | Medicine, Gastroenterology, Neurogastroenterology |
| Institutions | Mayo Clinic, Johns Hopkins University, University of Texas Medical Branch |
Education
editPasricha received his M.B.B.S. degree from the All-India Institute of Medical Sciences, New Delhi in 1982. He trained in internal medicine and pulmonology at Georgetown University-DC General Hospital and Tufts University-New England Medical Center. He further trained in gastroenterology at Johns Hopkins Hospital.[1]
Career
editAfter completing his fellowship in gastroenterology, Pasricha was appointed chair of the University of Texas Medical Branch in 1997, where he held the Bassel and Frances Blanton Distinguished Professorship in Internal Medicine.[2] In 2007, Pasricha moved to Stanford University School of Medicine where he served as Professor of Medicine and Surgery until 2012. He then returned to Johns Hopkins School of Medicine as Vice Chair of Medicine for innovation and commercialization and Director of the Johns Hopkins Center for Neurogastroenterology. In 2022, Pasricha moved to Mayo Clinic Arizona as Chair of the Department of Medicine.
His research work spans endoscopic, clinical and bench research. He has been a recipient of federal funding for his research since 1995 and is principal investigator on multiple NIH grants, and other awards. His clinical and research interests include GI motility disorders and abdominal pain, and the development of novel endoscopic procedures and devices[2]
Amongst his notable contributions to gastroenterology are the introduction of botulinum toxin as a therapeutic agent for gastrointestinal disorders, including achalasia[3] and sphincter of Oddi dysfunction.[4] He also introduced cryotherapy as a treatment modality for gastrointestinal disease.[5] Pasricha also developed the animal model for per-oral endoscopic myotomy (POEM), a third-space endoscopic treatment for achalasia. in the mid-2000s while at University of Texas Medical Branch, This was taken to fruition by Professor Haruhiro Inoue, a thoracic surgeon at Showa University Koto Toyosu Hospital in Tokyo, who further developed POEM in humans.[6]
On the bench research side, he pioneered the use of neural stem cell transplantation for disorders of gastrointestinal motility.[7] Notably, he demonstrated that the enteric nervous system is in a state of continual turnover, identifying the stem cell responsible for that in mice studies.[7] Pasricha also introduced the term “JAG-A” to encapsulate an emerging pattern of diseases demonstrating joint hypermobility, autonomic dysfunction gastrointestinal dysfunction and autoimmunity.[8]
Pasricha is the chair of the National Institutes of Health–funded multi-center Gastroparesis Clinical Research Consortium. He served on the National Commission on Digestive Diseases, appointed by the United States Congress to provide a roadmap for progress in gastrointestinal disorders. He is also the founding chair of the Center for Gastrointestinal Innovation and Technology, and has served on the Food and Drug Administration (FDA) GI Drug Advisory Committee.[2]
Pasricha has help found a number of companies in the medical and gastroenterology spaces, including Apollo Endosurgery, an endoscopic devices company co-developed with Peter B. Cotton, that forms part of Boston Scientific.[9][10]
Publications and patents
editPasricha has authored more than 300 manuscripts and book chapters, and holds more than 50 patents for novel gastrointestinal diagnosis and treatment methods. His contributions include chapters in the Cecil Textbook of Medicine, Yamada Textbook of Gastroenterology, and Goodman & Gilman's The Pharmacological Basis of Therapeutics.[2]
In terms of editorial roles, Pasricha has served as a senior editorial advisor for Digestive Diseases and Sciences, and as an associate editor for Gastroenterology, Journal of Pediatric Gastroenterology and Nutrition, and Gastrointestinal Endoscopy.[2]
Awards and recognition
editPasricha has received the American Gastroenterological Association Master's Award for Outstanding Sustained Achievement in Gastroenterology and the Nobility in Science Award from the National Pancreas Foundation.[2]
Personal life
editPasricha has been married to his wife, Reena, for nearly 30 years. They have three children.[2]
References
edit- ^ Pehlivanov, Nonko; Pasricha, Pankaj Jay (16 May 2006). "Principles of biomedical ethics". Gi Motility Online. Retrieved 2023-05-10.
- ^ a b c d e f g "AGA Honors and Awards Celebration". AGA GI Foundation. Retrieved 2023-05-10.
- ^ Pasricha, P. J.; Ravich, W. J.; Hendrix, T. R.; Sostre, S.; Jones, B.; Kalloo, A. N. (1994-10-15). "Treatment of achalasia with intrasphincteric injection of botulinum toxin. A pilot trial". Ann Intern Med. 121 (8): 590–591. doi:10.7326/0003-4819-121-8-199410150-00006. PMID 8085691. S2CID 44550062.
- ^ Pasricha, P. J.; Miskovsky, E. P.; Kalloo, A. N. (1994). "Intrasphincteric injection of botulinum toxin for suspected sphincter of Oddi dysfunction". Gut. 35 (9): 1319–1321. doi:10.1136/gut.35.9.1319. PMC 1375716. PMID 7959245.
- ^ Pasricha, P. J.; Hill, S.; Wadwa, K. S.; Gislason, G. T.; Okolo 3rd, P. I.; Magee, C. A.; Canto, M. I.; Kuo, W. H.; Baust, J. G.; Kalloo, A. N. (1999). "Endoscopic cryotherapy: experimental results and first clinical use". Gastrointest Endosc. 49 (5): 627–631. doi:10.1016/s0016-5107(99)70393-7. PMID 10228263.
{{cite journal}}: CS1 maint: numeric names: authors list (link) - ^ "Poem to ease esophageal passage". Johns Hopkins Medicine. 2018-06-13. Retrieved 2023-05-10.
- ^ a b Micci, Maria-Adelaide; Kahrig, Kristen M.; Simmons, Rochelle S.; Sarna, Sushil K.; Espejo-Navarro, M. Rosario; Pasricha, Pankaj Jay (2005). "Neural stem cell transplantation in the stomach rescues gastric function in neuronal nitric oxide synthase-deficient mice". Gastroenterology. 129 (6): 1817–1824. doi:10.1053/j.gastro.2005.08.055. PMID 16344050.
- ^ Karen Nitkin (2019-03-11). "Amos Food, Body and Mind Center Tackles Gut-Brain Connection". Johns Hopkins Medicine News. Retrieved 2023-06-07.
- ^ "UTMB helps launch Apollo Endosurgery; Startup company to commercialize new interventional devices for endoscopy and minimally invasive surgery". UTMB Newsroom. 2006-06-01. Retrieved 2023-06-07.
- ^ McKhann, Chas; Lee, Linda S. (2023). "Saving patients one stitch at a time?". IGIE. -- (2): 202–208. doi:10.1016/j.igie.2023.04.002.