Jefferson Historic District may refer to:
- in the United States
(by state)
- Jefferson Historic District (Jefferson, Alabama), listed on the NRHP in Alabama
- Jefferson Historic District (Jefferson, Georgia), listed on the NRHP in Jackson County, Georgia
- Jefferson Historic District (Lafayette, Indiana), listed on the NRHP in Tippecanoe County, Indiana
- Jefferson Historic District (Jefferson, Texas), listed on the NRHP in Marion County, Texas
- Jefferson Avenue Historic District (Ogden, Utah)