Jeffersonian refers to several fields upon which the U.S. President Thomas Jefferson had an impact:
- Jeffersonian architecture
- Jeffersonian democracy
- Jeffersonian Bible
- The Democratic-Republican Party were called Jeffersonians, among many other names
In fiction:
- The Jeffersonian Institute, a fictional research institution in the US television program Bones, based on the real Smithsonian Institution
In transportation:
- The Jeffersonian, a train operated by the Pennsylvania Railroad