Wikipedia

Jin-Quan Yu

The native form of this personal name is Yu Jin-Quan. This article uses Western name order when mentioning individuals.

Jin-Quan Yu (simplified Chinese: 余金权; traditional Chinese: 余金權; pinyin: Yú Jīn-quán) is a Chinese-born American chemist. He is the Frank and Bertha Hupp Professor of Chemistry at Scripps Research, where he also holds the Bristol Myers Squibb Endowed Chair in Chemistry.[1][2][3] He is a 2016 recipient of the MacArthur Fellowship,[4] and is a member of the American Academy of Arts and Sciences, American Association for the Advancement of Science, and the Royal Society of Chemistry.[3][5] Yu is a leader in the development of C–H bond activation reactions in organic chemistry, and has reported many C–H activation reactions that could be applicable towards the synthesis of drug molecules and other biologically active compounds. He also co-founded Vividion Therapeutics in 2016 with fellow Scripps chemists Benjamin Cravatt and Phil Baran,[6][7] and is a member of the scientific advisory board of Chemveda Life Sciences.[8]

Jin-Quan Yu
余金权
Born (1966-01-10) January 10, 1966 (age 58)
Zhejiang, China
Alma materUniversity of Cambridge Ph.D. (1999)

Guangzhou Institute of Chemistry M.Sc. (1990)

East China Normal University B.Sc. (1987)
Known forMeta-selective C–H functionalization
Scientific career
FieldsOrganic Chemistry, Organometallic chemistry, Carbon–hydrogen bond activation, Enantioselective synthesis
InstitutionsScripps Research (2007-present)

Brandeis University (2004-2007)

University of Cambridge (2003-2004)
Doctoral advisorJonathan B. Spencer
Other academic advisorsE. J. Corey
Websitewww.scripps.edu/yu/

Early life and education

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Yu was born on January 10, 1966, in Zhejiang, China.[9][10] He received his B.Sc. in chemistry at East China Normal University in 1987.[9] Yu then went on to the Guangzhou Institute of Chemistry, Chinese Academy of Sciences where he worked on heterogeneous reactions of terpenes with zeolite materials with Prof. Shu-De Xiao, obtaining his M.Sc. in 1990.[11][12] He remained at the Guangzhou Institute of Chemistry for four years as a research associate.[citation needed]

In 1994, Yu moved to the United Kingdom to pursue graduate studies at the University of Cambridge with Prof. Jonathan B. Spencer.[9] At Cambridge, he studied biosynthesis and the mechanistic details of the hydrometallation step in asymmetric hydrogenation reactions with heterogeneous and homogeneous catalysts, among the twenty-one papers he co-authored with Spencer.[13][14][15] Yu graduated with his Ph.D. in 1999.[9]

Between 1999 and 2001, Yu worked as a Junior Research Fellow of St John's College, Cambridge.[16][17] From 2001-2002, Yu worked as a postdoctoral fellow at Harvard University in the laboratory of Prof. E. J. Corey on selective palladium-catalyzed allylic oxidation reactions.[18][19][20] Yu returned to Cambridge in 2002 and continued in his position as a Junior Research Fellow.[21]

Independent career

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Yu was awarded a Royal Society University Research Fellowship in 2003, which allowed him to start his independent research towards the development of asymmetric C–H activation reactions.[21][3] In 2004, he moved to Brandeis University as an assistant professor of chemistry.[21] He moved to The Scripps Research Institute as an associate professor in 2007 and was promoted to full professor in 2010. In 2012, he was appointed the Frank and Bertha Hupp Professor of Chemistry.[2][3]

Research

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Yu is an organic synthetic chemist who develops of new methods for functionalizing carbon-hydrogen (C–H) bonds, or C–H activation.[22] A longstanding goal in organic synthesis, C–H activation would allow for inert, unreactive C–H bonds to be replaced with bonds to functional groups that can alter a molecule's reactivity and properties. One strategy to achieve selective C–H activation under mild conditions is to use metal-based catalysts that are guided to the targeted C–H bond by nearby directing functional groups. These directing groups often must be removed once the new functional group has been appended to the molecule.[4] This style of C–H activation methodology could greatly simplify the synthesis of pharmaceutical drug molecules, agrochemicals, and natural products.

Yu has contributed metal palladium-catalyzed C-H bond activation promoted by "weak coordination," that is by directing group effects.[23] Other areas of interest are the development of remote C-H bond activation, for example at the meta-position to a directing group.[24][25][26] Since many drugs and natural products are chiral, Yu has also developed important asymmetric C-H bond activation reactions, including those templated by modified amino acids that can act as transient, chiral directing groups.[27][28]

Awards and memberships

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Yu is the recipient of numerous awards and honors for his work in organic chemistry reaction development, including a MacArthur Fellowship (also known as a "Genius Grant") in 2016.[4] He was elected a member of the American Academy of Arts and Sciences in 2019,[5] a fellow of the American Association for the Advancement of Science and the Royal Society of Chemistry in 2012.[21] In 2013, he received the Raymond and Beverly Sackler Prize in the Physical Sciences.[29]

Yu received the Pedler Award from the Royal Society of Chemistry in 2016,[30] and the Elias J. Corey Award for Outstanding Original Contribution in Organic Synthesis by a Young Investigator from the American Chemical Society.[31] In 2012, he was awarded the Mukaiyama Award from the Japanese Society of Organic Synthesis,[32] the ACS Cope Scholar Award,[33] and the Bristol-Myers Squibb Award.[21] His honors also include the Novartis Early Career Award in Organic Chemistry (2011),[34] Eli Lilly Grantee Award (2008), Amgen Young Investigator's Award (2008),[21] and Sloan Research Fellowship (2008).[35]

Personal life

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Yu has a son, Tony.[9]

References

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  1. ^ Jennewein, Chris (2020-12-08). "McArthur Fellow Jin-Quan Yu Named to Newly-Endowed Chemistry Chair". Times of San Diego. Retrieved 2021-05-22.
  2. ^ a b "Yu, Jin-Quan". vivo.scripps.edu. Retrieved 2021-05-22.
  3. ^ a b c d "Jin-Quan Yu | Scripps Research". www.scripps.edu. Retrieved 2021-05-22.
  4. ^ a b c "Jin-Quan Yu". www.macfound.org. Retrieved 2021-05-22.
  5. ^ a b "Jin-Quan Yu". American Academy of Arts & Sciences. Retrieved 2021-05-22.
  6. ^ "Vividion Therapeutics: Creating a New Era in Drug Discovery". Retrieved 2021-05-23.
  7. ^ Fikes, Bradley J. "Vividion Therapeutics to get $101 million upfront from alliance with Celgene". chicagotribune.com. Retrieved 2021-05-23.
  8. ^ "Scientific Advisory Board | Chemveda Life Sciences". Retrieved 2021-05-23.
  9. ^ a b c d e "Jin-Quan Yu". Angewandte Chemie International Edition. 50 (22): 5014. 2011. doi:10.1002/anie.201101811. ISSN 1521-3773.
  10. ^ "Jin-Quan YU - Future Forum". www.futureforum.org.cn. Retrieved 2021-05-22.
  11. ^ Yu, Jin-Quan; Zhou, Ping; Xiao, Shu-De (1995). "Highly selective hydration reaction of α-pinene over H-mordenites pretreated with quaternary ammonium salts". Chinese Journal of Chemistry. 13 (3): 280–283. doi:10.1002/cjoc.19950130314. ISSN 1614-7065.
  12. ^ Bintang, Liu; Jinquan, Yu; Aiqun, Eng; Ping, Zhou; Shude, Xiao (1995-06-25). "Study on selective alkylation of guaiacol with camphene over H-Mordenite". Chinese Journal of Organic Chemistry. 15 (3): 318. ISSN 0253-2786.
  13. ^ Yu, Jinquan; Spencer, Jonathan B. (1997). "First Evidence That the Mechanism of Catalytic Hydrogenation with Homogeneous Palladium and Rhodium Catalysts Is Strongly Influenced by Substrate Polarity". Journal of the American Chemical Society. 119 (22): 5257–5258. doi:10.1021/ja964179i. ISSN 0002-7863.
  14. ^ Spencer, Jinquan Yu and Jonathan B. (1997). "Regioselective Hydrometalation of Alkenes Reveals the Amphipolar Nature of the Pd−H Bond in Heterogeneous Hydrogenation". The Journal of Organic Chemistry. 62 (25): 8618–8619. doi:10.1021/jo971602c. ISSN 0022-3263.
  15. ^ Yu, Jinquan (1998-01-01). "Discovery that quinoline and triphenylphosphine alter the electronic properties of hydrogenation catalysts". Chemical Communications (10): 1103–1104. doi:10.1039/A800629F. ISSN 1364-548X.
  16. ^ Yu, Jinquan; Gaunt, Matthew J.; Spencer, Jonathan B. (2002). "Convenient Preparation oftrans-Arylalkenes via Palladium(II)-Catalyzed Isomerization ofcis-Arylalkenes". The Journal of Organic Chemistry. 67 (13): 4627–4629. doi:10.1021/jo015880u. ISSN 0022-3263. PMID 12076172.
  17. ^ Yu, Jin-Quan; Wu, Hai-Chen; Ramarao, Chandrashekar; Spencer, Jonathan B.; Ley, Steven V. (2003-01-01). "Transfer hydrogenation using recyclable polyurea-encapsulated palladium: efficient and chemoselective reduction of aryl ketones". Chemical Communications (6): 678–679. doi:10.1039/B300074P. ISSN 1364-548X. PMID 12703769.
  18. ^ Yu, Jin-Quan; Corey, E. J. (2002-08-01). "Diverse Pathways for the Palladium(II)-Mediated Oxidation of Olefins by tert-Butylhydroperoxide". Organic Letters. 4 (16): 2727–2730. doi:10.1021/ol0262340. ISSN 1523-7060. PMID 12153220.
  19. ^ Yu, Jin-Quan; Corey, E. J. (2003-03-01). "A Mild, Catalytic, and Highly Selective Method for the Oxidation of α,β-Enones to 1,4-Enediones". Journal of the American Chemical Society. 125 (11): 3232–3233. doi:10.1021/ja0340735. ISSN 0002-7863. PMID 12630876.
  20. ^ Yu, Jin-Quan; Wu, Hai-Chen; Corey, E. J. (2005-03-01). "Pd(OH)2/C-Mediated Selective Oxidation of Silyl Enol Ethers by tert-Butylhydroperoxide, a Useful Method for the Conversion of Ketones to α,β-Enones or β-Silyloxy-α,β-enones". Organic Letters. 7 (7): 1415–1417. doi:10.1021/ol050284y. ISSN 1523-7060. PMID 15787520.
  21. ^ a b c d e f "The Yu Lab". www.scripps.edu. Retrieved 2021-05-23.
  22. ^ Yu, Jin-Quan (2014). "Directed C–H Activation Reactions of Synthetically Versatile Substrates: A Journey to Practicality". Advanced Synthesis & Catalysis. 356 (7): 1393. doi:10.1002/adsc.201400406. ISSN 1615-4169.
  23. ^ Engle, Keary M.; Mei, Tian-Sheng; Wasa, Masayuki; Yu, Jin-Quan (2011-12-14). "Weak Coordination as a Powerful Means for Developing Broadly Useful C–H Functionalization Reactions". Accounts of Chemical Research. 45 (6): 788–802. doi:10.1021/ar200185g. ISSN 0001-4842. PMC 3334399. PMID 22166158.
  24. ^ Leow, Dasheng; Li, Gang; Mei, Tian-Sheng; Yu, Jin-Quan (2012). "Activation of remote meta-C–H bonds assisted by an end-on template". Nature. 486 (7404): 518–522. doi:10.1038/nature11158. ISSN 0028-0836. PMC 3386562. PMID 22739317.
  25. ^ Zhang, Zhipeng; Tanaka, Keita; Yu, Jin-Quan (2017). "Remote site-selective C–H activation directed by a catalytic bifunctional template". Nature. 543 (7646): 538–542. doi:10.1038/nature21418. ISSN 1476-4687. PMC 5477648. PMID 28273068.
  26. ^ Wang, Xiao-Chen; Gong, Wei; Fang, Li-Zhen; Zhu, Ru-Yi; Li, Suhua; Engle, Keary M.; Yu, Jin-Quan (2015). "Ligand-enabled meta-C–H activation using a transient mediator". Nature. 519 (7543): 334–338. doi:10.1038/nature14214. ISSN 0028-0836. PMC 4368492. PMID 25754328.
  27. ^ Saint-Denis, Tyler G.; Zhu, Ru-Yi; Chen, Gang; Wu, Qing-Feng; Yu, Jin-Quan (2018-02-16). "Enantioselective C(sp3)‒H bond activation by chiral transition metal catalysts". Science. 359 (6377). doi:10.1126/science.aao4798. ISSN 0036-8075. PMC 5862070. PMID 29449462.
  28. ^ Shao, Qian; Wu, Kevin; Zhuang, Zhe; Qian, Shaoqun; Yu, Jin-Quan (2020-04-21). "From Pd(OAc)2 to Chiral Catalysts: The Discovery and Development of Bifunctional Mono-N-Protected Amino Acid Ligands for Diverse C–H Functionalization Reactions". Accounts of Chemical Research. 53 (4): 833–851. doi:10.1021/acs.accounts.9b00621. ISSN 0001-4842. PMC 7738004. PMID 32227915.
  29. ^ "CCHF | Event Report". www.nsf-cchf.com. Retrieved 2021-05-23.
  30. ^ "EuCheMS Chemistry Congress plenary speakers: Jin-Quan Yu". Royal Society of Chemistry. 2018-03-23. Retrieved 2021-05-23.
  31. ^ "CCHF | Event Report". www.nsf-cchf.com. Retrieved 2021-05-23.
  32. ^ "Mukaiyama Award | SSOCJ | The Society of Synthetic Organic Chemistry, Japan". Mukaiyama Award | SSOCJ | The Society of Synthetic Organic Chemistry, Japan. Retrieved 2021-05-23.
  33. ^ Drahl, Carmen (February 27, 2012). "Arthur C. Cope Scholar: Jin-Quan Yu". cen.acs.org. Retrieved 2021-05-23.
  34. ^ "Novartis Early Career Award in Organic Chemistry 2011 :: News :: ChemistryViews". www.chemistryviews.org. Retrieved 2021-05-23.
  35. ^ "2008 Annual Report - Alfred P. Sloan Foundation" (PDF).
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