Joël Bockaert

Joël Bockaert (born 3 October 1945, in Roubaix) is a French biologist.

Biography

He was a student at the École Normale d'Instituteur in Mérignac (33) from 1961 to 1964 and at the École Normale supérieure-Rue d'Ulm-Paris from 1964 to 1968.

Graduate in Natural Sciences (1968), he completed his thesis work at the Collège de France and his post-doctoral internship at Northwestern University in Chicago. He was successively a professor at the University of Paris VI (1968–73), deputy director of the Chair of Cell Physiology at the Collège de France (1973–82) before being, in Montpellier, Director of Research at the CNRS (1982-2001) then Professor at the University of Montpellier (2001-2014).

In Montpellier, he founded the CNRS-INSERM Institute of Pharmacology-Endocrinology (1982), of which he was Director from 1990 to 2005 and then the Institute of Functional Genomics.^[1] In 2013, he became Director of the Biology and Health Department of Montpellier.^[2]

Scientific work

Joël Bockaert's work has been devoted to the study of intercellular communications and in particular those involved in the brain.^[3]^[4]^[5]^[6]

Joël Bockaert was one of the pioneers in the study of molecules responsible for recognizing and interpreting the messages of intercellular communication known as "receptors". He specialized in the study of a family of receptors called "G-protein coupled receptors or GPCGs". He will discover some of them, including oxytocin, vasopressin,^[7] metabotropic brain glutamate^[8]^[9]^[10]^[11]^[12]^[13] and serotonin^[14] receptors. The latter modulate cognitive and emotional functions. The family of GPCRs is of considerable physiological importance. It is these receptors that capture light (ensuring vision), which recognize bitter, sweet or umami tastes, smells but also the majority of hormones and neurotransmitters1,2.

Given their roles, these receptors are the direct or indirect target of more than 40% of drugs sold in pharmacies to treat hypertension, allergies, migraine, depression, parkinson's disease or pain.^[1]^[2]

Societies and academies

1992-1995 President of the Society of Neurosciences

1996: Member of EMBO

He was elected a corresponding member of the French Academy of sciences in 1996 and a member in 2003.^[15]

In 2017, he became a member of the Academy of sciences and letters of Montpellier

Awards and honours

Rochat-Julliard Prize of the French Academy of sciences
Charles-Léopold Mayer Grand Prize of the Academy of Sciences
Lilly - ECNP Prize
Honorary Professor of Huazhong University (China) and recipient of the China and Friendship Award
Doctor Honoris Causa Université libre de Bruxelles

Decorations

Chevalier of the Légion d'Honneur
Chevalier of the Palmes Académiques

References

^ ^a ^b "Institut de génomique fonctionnelle".
^ ^a ^b "Pôle Biologie-Santé de Montpellier".
^ Bockaert J, « Molecular tinkering of G protein-coupled receptors: an evolutionary success », Embo Journal, (1999) 18, p. 1723-1729
^ Joël Bockaert,La communication du vivant , Paris, Odile Jacob, 2017
^ "Canal Académie".
^ "Maison de la chimie". 9 April 2018.
^ Jard S, « Stimulus-response coupling in neurohypophysial peptide target cells. », Physiological Review, 1975 (5554), p. 489-536
^ Sladeczek F., « Glutamate stiumates inositol phosphate formation in striatal neurones », Nature, (1985) 317, p. 717-719
^ Dumuis A, « Arachidonic acid released from striatal neurons by joint stimulation of ionotropic and metabotropic quisqualate receptors », Nature, (1990) 347, p. 182-4
^ Ango, F, « Agonist independent activation of mGluRs by intracellular protein Homer », Nature, (2001) 411, p. 962-966
^ Dumuis A., « NMDA receptors activate the arachidonic acid cascade system in striatal neurons. », Nature, (1988) 336, p. 68-70
^ Lafon-Cazal M., « NMDA-dependent superoxide production and neurotoxicity », Nature, (1993) 364, p. 535-537
^ Bertaso F, « PICK1 uncoupling from mGluR7a causes absence-like seizures », Nature Neuroscience, (2008) 8, p. 940-8
^ Bockaert J, « 5-HT(4) receptors, a place in the sun: act two », Curr Opin Pharmacol., (2011) 11, p. 87-93
^ "Académie des sciences".

[:0-1] "Institut de génomique fonctionnelle".

[:1-2] "Pôle Biologie-Santé de Montpellier".

[3] Bockaert J, « Molecular tinkering of G protein-coupled receptors: an evolutionary success », Embo Journal, (1999) 18, p. 1723-1729

[4] Joël Bockaert,La communication du vivant , Paris, Odile Jacob, 2017

[5] "Canal Académie".

[6] "Maison de la chimie". 9 April 2018.

[7] Jard S, « Stimulus-response coupling in neurohypophysial peptide target cells. », Physiological Review, 1975 (5554), p. 489-536

[8] Sladeczek F., « Glutamate stiumates inositol phosphate formation in striatal neurones », Nature, (1985) 317, p. 717-719

[9] Dumuis A, « Arachidonic acid released from striatal neurons by joint stimulation of ionotropic and metabotropic quisqualate receptors », Nature, (1990) 347, p. 182-4

[10] Ango, F, « Agonist independent activation of mGluRs by intracellular protein Homer », Nature, (2001) 411, p. 962-966

[11] Dumuis A., « NMDA receptors activate the arachidonic acid cascade system in striatal neurons. », Nature, (1988) 336, p. 68-70

[12] Lafon-Cazal M., « NMDA-dependent superoxide production and neurotoxicity », Nature, (1993) 364, p. 535-537

[13] Bertaso F, « PICK1 uncoupling from mGluR7a causes absence-like seizures », Nature Neuroscience, (2008) 8, p. 940-8

[14] Bockaert J, « 5-HT(4) receptors, a place in the sun: act two », Curr Opin Pharmacol., (2011) 11, p. 87-93

[15] "Académie des sciences".

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]