José Flores may refer to:
- Jose Flores (baseball coach) (born 1971), Puerto Rican baseball coach
- Jose Flores (infielder) (born 1973), American baseball player
- Jose Flores (jockey) (1960–2018), Peruvian-American jockey
- José Flores (Venezuelan footballer) (born 1967), Venezuelan footballer
- José Flores (weightlifter) (born 1930), Dutch Antillean weightlifter
- José Felipe Flores (1751–1824), physician and medicine teaching pioneer in Central America
- José María Flores (1818–1866), officer in the Mexican Army
- José Oscar Flores (born 1971), Argentine footballer