KATNA1

KATNA1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2RPA
Identifiers
Aliases	KATNA1, katanin catalytic subunit A1
External IDs	OMIM: 606696; MGI: 1344353; HomoloGene: 56014; GeneCards: KATNA1; OMA:KATNA1 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	149,648,972 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	7,638,914 bp
RNA expression pattern
	Top expressed in
	sperm; ; secondary oocyte; ; gonad; ; left testis; ; right testis; ; Achilles tendon; ; retinal pigment epithelium; ; testicle; ; gastrocnemius muscle; ; Descending thoracic aorta;
	Top expressed in
	granulocyte; ; epiblast; ; bone marrow; ; zygote; ; zone of skin; ; ileum; ; primary oocyte; ; thymus; ; secondary oocyte; ; esophagus;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; microtubule binding; microtubule-severing ATPase activity; protein binding; protein heterodimerization activity; hydrolase activity; ATP binding; ATPase activity; isomerase activity;
Cellular component	cytoplasm; spindle pole; midbody; microtubule; cytoskeleton; nucleus; microtubule organizing center; spindle; mitotic spindle pole; centrosome;
Biological process	cell division; microtubule severing; cell cycle; cytoplasmic microtubule organization;
	Sources:Amigo / QuickGO
Orthologs
	11104
	23924
	ENSG00000186625
	ENSMUSG00000019794
	O75449
	Q9WV86
	NM_001204076; NM_007044
	NM_011835
	NP_001191005; NP_008975
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Katanin p60 ATPase-containing subunit A1 is an enzyme that in humans is encoded by the KATNA1 gene.^[5]^[6]

Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. This gene encodes the p80 subunit. This protein is a member of the AAA family of ATPases.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000186625 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000019794 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ McNally FJ, Thomas S (Jan 1999). "Katanin is responsible for the M-phase microtubule-severing activity in Xenopus eggs". Mol Biol Cell. 9 (7): 1847–61. doi:10.1091/mbc.9.7.1847. PMC 25426. PMID 9658175.
^ ^a ^b "Entrez Gene: KATNA1 katanin p60 (ATPase-containing) subunit A 1".

McNally FJ, Vale RD (1993). "Identification of katanin, an ATPase that severs and disassembles stable microtubules". Cell. 75 (3): 419–29. doi:10.1016/0092-8674(93)90377-3. PMID 8221885. S2CID 10264319.
McNally FJ, Okawa K, Iwamatsu A, Vale RD (1997). "Katanin, the microtubule-severing ATPase, is concentrated at centrosomes". J. Cell Sci. 109 (3): 561–7. doi:10.1242/jcs.109.3.561. PMID 8907702.
Hartman JJ, Mahr J, McNally K, et al. (1998). "Katanin, a microtubule-severing protein, is a novel AAA ATPase that targets to the centrosome using a WD40-containing subunit". Cell. 93 (2): 277–87. doi:10.1016/S0092-8674(00)81578-0. PMID 9568719. S2CID 13583382.
Ahmad FJ, Yu W, McNally FJ, Baas PW (1999). "An essential role for katanin in severing microtubules in the neuron". J. Cell Biol. 145 (2): 305–15. doi:10.1083/jcb.145.2.305. PMC 2133110. PMID 10209026.
Syu LJ, Saltiel AR (1999). "Lipotransin: a novel docking protein for hormone-sensitive lipase". Mol. Cell. 4 (1): 109–15. doi:10.1016/S1097-2765(00)80192-6. PMID 10445032.
McNally KP, Bazirgan OA, McNally FJ (2000). "Two domains of p80 katanin regulate microtubule severing and spindle pole targeting by p60 katanin". J. Cell Sci. 113 (9): 1623–33. doi:10.1242/jcs.113.9.1623. PMID 10751153.
Buster D, McNally K, McNally FJ (2002). "Katanin inhibition prevents the redistribution of gamma-tubulin at mitosis". J. Cell Sci. 115 (Pt 5): 1083–92. doi:10.1242/jcs.115.5.1083. PMID 11870226.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000186625 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000019794 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9658175-5] McNally FJ, Thomas S (Jan 1999). "Katanin is responsible for the M-phase microtubule-severing activity in Xenopus eggs". Mol Biol Cell. 9 (7): 1847–61. doi:10.1091/mbc.9.7.1847. PMC 25426. PMID 9658175.

[entrez-6] "Entrez Gene: KATNA1 katanin p60 (ATPase-containing) subunit A 1".

[5]

[6]

[1]

[2]

[3]

[4]

KATNA1

References

Further reading