KCNA6

Potassium voltage-gated channel subfamily A member 6 also known as K_v1.6 is a protein that in humans is encoded by the KCNA6 gene. The protein encoded by this gene is a voltage-gated potassium channel subunit.

KCNA6
Identifiers
Aliases	KCNA6, HBK2, KV1.6, PPP1R96, potassium voltage-gated channel subfamily A member 6
External IDs	OMIM: 176257; MGI: 96663; HomoloGene: 1684; GeneCards: KCNA6; OMA:KCNA6 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) Band 12p13.32 Start 4,809,334 bp End 4,813,318 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6 F3|6 61.72 cM Start 126,685,292 bp End 126,717,637 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle prefrontal cortex islet of Langerhans ventricular zone Brodmann area 9 Achilles tendon cingulate gyrus right frontal lobe anterior cingulate cortex ganglionic eminence Top expressed in dentate gyrus of hippocampal formation granule cell lumbar spinal ganglion medial dorsal nucleus superior frontal gyrus lateral hypothalamus globus pallidus primary visual cortex medial vestibular nucleus trigeminal ganglion cerebellar cortex More reference expression data BioGPS n/a
Gene ontology Molecular function voltage-gated potassium channel activity ion channel activity potassium channel activity delayed rectifier potassium channel activity voltage-gated ion channel activity Cellular component axon terminus integral component of membrane voltage-gated potassium channel complex axon plasma membrane potassium channel complex integral component of plasma membrane membrane Biological process potassium ion transport regulation of ion transmembrane transport protein homooligomerization ion transport transmembrane transport potassium ion transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3742 16494 Ensembl ENSG00000151079 ENSMUSG00000038077 UniProt P17658 Q61923 RefSeq (mRNA) NM_002235 NM_013568 RefSeq (protein) NP_002226 NP_038596 Location (UCSC) Chr 12: 4.81 – 4.81 Mb Chr 6: 126.69 – 126.72 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Albrecht B, Weber K, Pongs O (1995). "Characterization of a voltage-activated K-channel gene cluster on human chromosome 12p13". Recept. Channels. 3 (3): 213–20. PMID 8821794.
• Tan KM, Lennon VA, Klein CJ, et al. (2008). "Clinical spectrum of voltage-gated potassium channel autoimmunity". Neurology. 70 (20): 1883–90. doi:10.1212/01.wnl.0000312275.04260.a0. PMID 18474843. S2CID 34815377.
• Grupe A, Schröter KH, Ruppersberg JP, et al. (1990). "Cloning and expression of a human voltage-gated potassium channel. A novel member of the RCK potassium channel family". EMBO J. 9 (6): 1749–56. doi:10.1002/j.1460-2075.1990.tb08299.x. PMC 551878. PMID 2347305.
• Yusifov T, Savalli N, Gandhi CS, et al. (2008). "The RCK2 domain of the human BKCa channel is a calcium sensor". Proc. Natl. Acad. Sci. U.S.A. 105 (1): 376–81. Bibcode:2008PNAS..105..376Y. doi:10.1073/pnas.0705261105. PMC 2224220. PMID 18162557.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

External links

• Kv1.6+Potassium+Channel at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• KCNA6+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)