KCNJ16

Potassium inwardly-rectifying channel, subfamily J, member 16 (KCNJ16) is a human gene encoding the K_ir5.1 protein.

KCNJ16
Identifiers
Aliases	KCNJ16, BIR9, KIR5.1, potassium voltage-gated channel subfamily J member 16, potassium inwardly rectifying channel subfamily J member 16, HKTD
External IDs	OMIM: 605722; MGI: 1314842; HomoloGene: 23112; GeneCards: KCNJ16; OMA:KCNJ16 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17q24.3 Start 70,053,429 bp End 70,135,608 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11 E2|11 75.01 cM Start 110,858,859 bp End 110,918,794 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in renal medulla kidney tubule caput epididymis dorsal motor nucleus of vagus nerve glomerulus thyroid gland human kidney metanephric glomerulus left lobe of thyroid gland right lobe of thyroid gland Top expressed in human kidney right kidney epithelium of stomach proximal tubule lumbar subsegment of spinal cord vestibular membrane of cochlear duct otolith organ utricle deep cerebellar nuclei submandibular gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function voltage-gated ion channel activity inward rectifier potassium channel activity G-protein activated inward rectifier potassium channel activity Cellular component integral component of membrane voltage-gated potassium channel complex plasma membrane basolateral plasma membrane integral component of plasma membrane membrane Biological process potassium ion transport regulation of ion transmembrane transport ion transport potassium ion import across plasma membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3773 16517 Ensembl ENSG00000153822 ENSMUSG00000051497 UniProt Q9NPI9 Q9Z307 RefSeq (mRNA) NM_001270422 NM_001291622 NM_001291623 NM_001291624 NM_001291625 NM_018658 NM_170741 NM_170742 NM_001252207 NM_001252208 NM_001252209 NM_001252210 NM_010604 RefSeq (protein) NP_001257351 NP_001278551 NP_001278552 NP_001278553 NP_001278554 NP_061128 NP_733937 NP_733938 NP_001239136 NP_001239137 NP_001239138 NP_001239139 NP_034734 Location (UCSC) Chr 17: 70.05 – 70.14 Mb Chr 11: 110.86 – 110.92 Mb PubMed search
Wikidata
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Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. K_ir5.1 is an integral membrane protein and inward-rectifier type potassium channel. K_ir5.1, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, can form heterodimers with two other inward-rectifier type potassium channels. It may be involved in the regulation of fluid and pH balance. Three transcript variants encoding the same protein have been found for this gene.

See also

• Inward-rectifier potassium ion channel

Further reading

• Kubo Y, Adelman JP, Clapham DE, et al. (2006). "International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels". Pharmacol. Rev. 57 (4): 509–26. doi:10.1124/pr.57.4.11. PMID 16382105. S2CID 11588492.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Pearson WL, Dourado M, Schreiber M, et al. (1999). "Expression of a functional Kir4 family inward rectifier K+ channel from a gene cloned from mouse liver". J. Physiol. 514 ( Pt 3) (3): 639–53. doi:10.1111/j.1469-7793.1999.639ad.x. PMC 2269105. PMID 9882736.
• Liu Y, McKenna E, Figueroa DJ, et al. (2000). "The human inward rectifier K(+) channel subunit kir5.1 (KCNJ16) maps to chromosome 17q25 and is expressed in kidney and pancreas". Cytogenet. Cell Genet. 90 (1–2): 60–3. doi:10.1159/000015662. PMID 11060447. S2CID 26933916.
• Derst C, Karschin C, Wischmeyer E, et al. (2001). "Genetic and functional linkage of Kir5.1 and Kir2.1 channel subunits". FEBS Lett. 491 (3): 305–11. Bibcode:2001FEBSL.491..305D. doi:10.1016/S0014-5793(01)02202-5. PMID 11240146. S2CID 14452157.
• Pessia M, Imbrici P, D'Adamo MC, et al. (2001). "Differential pH sensitivity of Kir4.1 and Kir4.2 potassium channels and their modulation by heteropolymerisation with Kir5.1". J. Physiol. 532 (Pt 2): 359–67. doi:10.1111/j.1469-7793.2001.0359f.x. PMC 2278540. PMID 11306656.
• Tanemoto M, Fujita A, Higashi K, Kurachi Y (2002). "PSD-95 mediates formation of a functional homomeric Kir5.1 channel in the brain". Neuron. 34 (3): 387–97. doi:10.1016/S0896-6273(02)00675-X. PMID 11988170. S2CID 15862428.
• Konstas AA, Korbmacher C, Tucker SJ (2003). "Identification of domains that control the heteromeric assembly of Kir5.1/Kir4.0 potassium channels". Am. J. Physiol., Cell Physiol. 284 (4): C910–7. doi:10.1152/ajpcell.00479.2002. PMID 12456399. S2CID 2525019.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Casamassima M, D'Adamo MC, Pessia M, Tucker SJ (2003). "Identification of a heteromeric interaction that influences the rectification, gating, and pH sensitivity of Kir4.1/Kir5.1 potassium channels". J. Biol. Chem. 278 (44): 43533–40. doi:10.1074/jbc.M306596200. PMID 12923169.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.