KCNQ1 downstream neighbour (KCNQ1DN) is a long non-coding RNA gene. In humans, it is located on chromosome 11p15.5 between the CDKN1C and KCNQ1 genes. It is an imprinted gene, expressed from the maternal allele. Reduced expression of KCNQ1DN is observed in Wilms' tumours.[3]
| KCNQ1DN | |||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | KCNQ1DN, BWRT, HSA404617, KCNQ1 downstream neighbor (non-protein coding), KCNQ1 downstream neighbor | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 610980; GeneCards: KCNQ1DN; OMA:KCNQ1DN - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| KCNQ1 downstream neighbour | |
|---|---|
 Predicted secondary structure and sequence conservation of KCNQ1DN | |
| Identifiers | |
| Symbol | KCNQ1DN |
| Rfam | RF01961 |
| Other data | |
| RNA type | Gene; |
| Domain(s) | Eukaryota; |
| SO | SO:0001463 |
| PDB structures | PDBe |
See also
editReferences
edit- ^ a b c ENSG00000278855 GRCh38: Ensembl release 89: ENSG00000237941, ENSG00000278855 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Xin Z, Soejima H, Higashimoto K, et al. (November 2000). "A novel imprinted gene, KCNQ1DN, within the WT2 critical region of human chromosome 11p15.5 and its reduced expression in Wilms' tumors". J. Biochem. 128 (5): 847–853. doi:10.1093/oxfordjournals.jbchem.a022823. PMID 11056398.
Further reading
edit- Engemann S, Strodicke M, Paulsen M, et al. (2000). "Sequence and functional comparison in the Beckwith-Wiedemann region: implications for a novel imprinting centre and extended imprinting". Hum. Mol. Genet. 9 (18): 2691–2706. doi:10.1093/hmg/9.18.2691. PMID 11063728.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.