KDEF may refer to:
- KDEF-LP, a defunct low-power radio station (101.5 FM) formerly licensed to serve Adelanto, California, United States
- KNMM, a radio station (1150 AM) licensed to serve Albuquerque, New Mexico, United States, which held the call sign KDEF from 1982 to 2017
This disambiguation page lists articles about radio and/or television stations with the same/similar call signs or branding.
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