KIF2C

Kinesin-like protein KIF2C is a protein that in humans is encoded by the KIF2C gene.

KIF2C
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2HEH, 4UBF, 4Y05
Identifiers
Aliases	KIF2C, CT139, KNSL6, MCAK, kinesin family member 2C
External IDs	OMIM: 604538; MGI: 1921054; HomoloGene: 21355; GeneCards: KIF2C; OMA:KIF2C - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1p34.1 Start 44,739,818 bp End 44,767,767 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4 D1|4 53.42 cM Start 117,016,836 bp End 117,039,836 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte ventricular zone right testis left testis sperm embryo ganglionic eminence gonad testicle bone marrow Top expressed in otic placode seminiferous tubule otic vesicle primary oocyte saccule primitive streak maxillary prominence spermatid endothelial cell of lymphatic vessel mandibular prominence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding microtubule binding microtubule plus-end binding centromeric DNA binding ATPase activity protein binding ATP binding microtubule motor activity Cellular component cytoplasm membrane kinesin complex microtubule cytoskeleton chromosome microtubule plus-end cytoplasmic microtubule chromosome, centromeric region cytoskeleton microtubule nucleus kinetochore nucleoplasm centrosome cytosol Biological process antigen processing and presentation of exogenous peptide antigen via MHC class II establishment or maintenance of microtubule cytoskeleton polarity chromosome segregation cell division regulation of chromosome segregation microtubule-based movement cell cycle microtubule depolymerization mitotic metaphase plate congression cell population proliferation retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum sister chromatid cohesion metaphase plate congression attachment of mitotic spindle microtubules to kinetochore mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11004 73804 Ensembl ENSG00000142945 ENSMUSG00000028678 UniProt Q99661 Q922S8 RefSeq (mRNA) NM_001297655 NM_001297656 NM_001297657 NM_006845 NM_001290662 NM_134471 RefSeq (protein) NP_001284584 NP_001284585 NP_001284586 NP_006836 NP_001277591 NP_608301 Location (UCSC) Chr 1: 44.74 – 44.77 Mb Chr 4: 117.02 – 117.04 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a member of kinesin-like protein family, and contains common ATPase site structures such as the P-loop, Switch 1, and Switch 2. Most proteins of this family are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein acts to regulate microtubule dynamics in cells and is important for anaphase chromosome segregation and may be required to coordinate the onset of sister centromere separation.

A ribbon and surface diagram of the KIF2C motor domain. The kinesin structure is pseudo-colored to highlight the ATPase site with a bound nucleotide. The figure then presents KIF2C binding to the tubulin dimer and finally visualizes a KIF2C motor head in the context of the microtubule filament.

Further reading

• Miki H, Setou M, Kaneshiro K, Hirokawa N (June 2001). "All kinesin superfamily protein, KIF, genes in mouse and human". Proceedings of the National Academy of Sciences of the United States of America. 98 (13): 7004–7011. Bibcode:2001PNAS...98.7004M. doi:10.1073/pnas.111145398. PMC 34614. PMID 11416179.
• Maney T, Hunter AW, Wagenbach M, Wordeman L (August 1998). "Mitotic centromere-associated kinesin is important for anaphase chromosome segregation". The Journal of Cell Biology. 142 (3): 787–801. doi:10.1083/jcb.142.3.787. PMC 2148171. PMID 9700166.
• Wordeman L, Wagenbach M, Maney T (2000). "Mutations in the ATP-binding domain affect the subcellular distribution of mitotic centromere-associated kinesin (MCAK)". Cell Biology International. 23 (4): 275–286. doi:10.1006/cbir.1999.0359. PMID 10600236. S2CID 29403722.
• Sugata N, Li S, Earnshaw WC, Yen TJ, Yoda K, Masumoto H, et al. (November 2000). "Human CENP-H multimers colocalize with CENP-A and CENP-C at active centromere--kinetochore complexes". Human Molecular Genetics. 9 (19): 2919–2926. doi:10.1093/hmg/9.19.2919. PMID 11092768.
• Maney T, Wagenbach M, Wordeman L (September 2001). "Molecular dissection of the microtubule depolymerizing activity of mitotic centromere-associated kinesin". The Journal of Biological Chemistry. 276 (37): 34753–34758. doi:10.1074/jbc.M106626200. PMID 11466324.
• Cheng LJ, Zhou ZM, Li JM, Zhu H, Zhu H, Zhou YD, et al. (October 2002). "Expression of a novel HsMCAK mRNA splice variant, tsMCAK gene, in human testis". Life Sciences. 71 (23): 2741–2757. doi:10.1016/S0024-3205(02)02079-9. PMID 12383881.
• Cassimeris L, Morabito J (April 2004). "TOGp, the human homolog of XMAP215/Dis1, is required for centrosome integrity, spindle pole organization, and bipolar spindle assembly". Molecular Biology of the Cell. 15 (4): 1580–1590. doi:10.1091/mbc.E03-07-0544. PMC 379257. PMID 14718566.
• Ganem NJ, Compton DA (August 2004). "The KinI kinesin Kif2a is required for bipolar spindle assembly through a functional relationship with MCAK". The Journal of Cell Biology. 166 (4): 473–478. doi:10.1083/jcb.200404012. PMC 2172212. PMID 15302853.
• Newton CN, Wagenbach M, Ovechkina Y, Wordeman L, Wilson L (August 2004). "MCAK, a Kin I kinesin, increases the catastrophe frequency of steady-state HeLa cell microtubules in an ATP-dependent manner in vitro". FEBS Letters. 572 (1–3): 80–84. doi:10.1016/j.febslet.2004.06.093. PMID 15304328.
• Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (January 2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
• Moore AT, Rankin KE, von Dassow G, Peris L, Wagenbach M, Ovechkina Y, et al. (May 2005). "MCAK associates with the tips of polymerizing microtubules". The Journal of Cell Biology. 169 (3): 391–397. doi:10.1083/jcb.200411089. PMC 2171944. PMID 15883193.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Ganem NJ, Upton K, Compton DA (October 2005). "Efficient mitosis in human cells lacking poleward microtubule flux". Current Biology. 15 (20): 1827–1832. Bibcode:2005CBio...15.1827G. doi:10.1016/j.cub.2005.08.065. PMID 16243029. S2CID 8541946.
• Helenius J, Brouhard G, Kalaidzidis Y, Diez S, Howard J (May 2006). "The depolymerizing kinesin MCAK uses lattice diffusion to rapidly target microtubule ends". Nature. 441 (7089): 115–119. Bibcode:2006Natur.441..115H. CiteSeerX 10.1.1.392.1014. doi:10.1038/nature04736. PMID 16672973. S2CID 4408328.
• Sun Y, Huang YC, Xu QZ, Wang HP, Bai B, Sui JL, Zhou PK (July 2006). "HIV-1 Tat depresses DNA-PK(CS) expression and DNA repair, and sensitizes cells to ionizing radiation". International Journal of Radiation Oncology, Biology, Physics. 65 (3): 842–850. doi:10.1016/j.ijrobp.2006.02.040. PMID 16751065.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

External links

• Overview of all the structural information available in the PDB for UniProt: Q99661 (Kinesin-like protein KIF2C) at the PDBe-KB.