KIFC1

Kinesin-like protein KIFC1 is a protein that in humans is encoded by the KIFC1 gene.

KIFC1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2REP
Identifiers
Aliases	KIFC1, HSET, KNSL2, kinesin family member C1
External IDs	OMIM: 603763; MGI: 2137414; HomoloGene: 83229; GeneCards: KIFC1; OMA:KIFC1 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6p21.32 Start 33,391,823 bp End 33,409,896 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17|17 A3.3 Start 27,136,065 bp End 27,151,557 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence gonad bone marrow mucosa of transverse colon lymph node appendix stromal cell of endometrium bone marrow cells right testis Top expressed in bone marrow yolk sac epiblast urethra ventricular zone thymus hair granulocyte placenta tail of embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding microtubule binding ATPase activity ATP binding microtubule motor activity minus-end-directed microtubule motor activity Cellular component cytoplasm endosome membrane kinesin complex spindle microtubule organizing center early endosome microtubule cytoskeleton nucleus mitotic spindle Biological process cell division mitotic spindle assembly spermatogenesis mitotic sister chromatid segregation cell cycle mitotic metaphase plate congression microtubule-based movement Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3833 16580 Ensembl ENSG00000233450 ENSG00000204197 ENSG00000237649 ENSG00000056678 ENSMUSG00000024301 UniProt Q9BW19 Q9QWT9 RefSeq (mRNA) NM_002263 NM_016761 NM_053173 RefSeq (protein) NP_002254 NP_001182227 Location (UCSC) Chr 6: 33.39 – 33.41 Mb Chr 17: 27.14 – 27.15 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein KifC1 is a member of kinesin-14 family. KifC1 consists of C-terminal motor domain, superhelical stalk and N-terminal tail domain. Tail and motor domains contain microtubule-binding sites. This kinesin moves towards the minus-end of microtubule and has an ability to slide or crosslink microtubules. KifC1 functions during mitotic spindle formation.

Further reading

• Miki H, Setou M, Kaneshiro K, Hirokawa N (2001). "All kinesin superfamily protein, KIF, genes in mouse and human". Proc. Natl. Acad. Sci. U.S.A. 98 (13): 7004–7011. Bibcode:2001PNAS...98.7004M. doi:10.1073/pnas.111145398. PMC 34614. PMID 11416179.
• Janitz K, Wild A, Beck S, Savasta S, Beluffi G, Ziegler A, Volz A (1999). "Genomic organization of the HSET locus and the possible association of HLA-linked genes with immotile cilia syndrome (ICS)". Immunogenetics. 49 (7–8): 644–652. doi:10.1007/s002510050660. PMID 10369922. S2CID 25729892.
• Neef R, Preisinger C, Sutcliffe J, Kopajtich R, Nigg EA, Mayer TU, Barr FA (2003). "Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis" (PDF). J. Cell Biol. 162 (5): 863–875. doi:10.1083/jcb.200306009. PMC 2172827. PMID 12939256.
• Gruneberg U, Neef R, Honda R, Nigg EA, Barr FA (2004). "Relocation of Aurora B from centromeres to the central spindle at the metaphase to anaphase transition requires MKlp2". J. Cell Biol. 166 (2): 167–172. doi:10.1083/jcb.200403084. PMC 2172317. PMID 15263015.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Al-Bassam J, Roger B, Halpain S, Milligan RA (2007). "Analysis of the weak interactions of ADP-Unc104 and ADP-kinesin with microtubules and their inhibition by MAP2c". Cell Motil. Cytoskeleton. 64 (5): 377–389. doi:10.1002/cm.20190. PMID 17326138.

External links

• Overview of all the structural information available in the PDB for UniProt: Q9BW19 (Human Kinesin-like protein KIFC1) at the PDBe-KB.