Krueppel-like factor 5 is a protein that in humans is encoded by the KLF5 gene.[5][6]

KLF5
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesKLF5, BTEB2, CKLF, IKLF, Kruppel-like factor 5 (intestinal), Kruppel like factor 5
External IDsOMIM: 602903; MGI: 1338056; HomoloGene: 37520; GeneCards: KLF5; OMA:KLF5 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001730
NM_001286818

NM_009769

RefSeq (protein)

NP_001273747
NP_001721

NP_033899

Location (UCSC)Chr 13: 73.05 – 73.08 MbChr 14: 99.54 – 99.55 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. Since the protein localizes to the nucleus and binds the epidermal growth factor response element, it is thought to be a transcription factor.[6]

Interactions

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KLF5 has been shown to interact with Protein SET.[7]

Clinical significance

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KLF5 expression has been linked to higher survival rates for lung cancer patients.[8]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000102554Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000005148Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Sogawa K, Imataka H, Yamasaki Y, Kusume H, Abe H, Fujii-Kuriyama Y (Apr 1993). "cDNA cloning and transcriptional properties of a novel GC box-binding protein, BTEB2". Nucleic Acids Research. 21 (7): 1527–32. doi:10.1093/nar/21.7.1527. PMC 309358. PMID 8479902.
  6. ^ a b "Entrez Gene: KLF5 Kruppel-like factor 5 (intestinal)".
  7. ^ Miyamoto S, Suzuki T, Muto S, Aizawa K, Kimura A, Mizuno Y, Nagino T, Imai Y, Adachi N, Horikoshi M, Nagai R (Dec 2003). "Positive and negative regulation of the cardiovascular transcription factor KLF5 by p300 and the oncogenic regulator SET through interaction and acetylation on the DNA-binding domain". Molecular and Cellular Biology. 23 (23): 8528–41. doi:10.1128/MCB.23.23.8528-8541.2003. PMC 262669. PMID 14612398.
  8. ^ "Research update from the MCM team (May 2024)". World Community Grid. 13 May 2024. Retrieved 21 May 2024.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.