KLF8

Krueppel-like factor 8 is a protein that in humans is encoded by the KLF8 gene. KLF8 belongs to the family of KLF protein. KLF8 is activated by KLF1 along with KLF3 while KLF3 represses KLF8.

KLF8
Identifiers
Aliases	KLF8, BKLF3, ZNF741, Kruppel-like factor 8, Kruppel like factor 8
External IDs	OMIM: 300286; MGI: 2442430; HomoloGene: 68549; GeneCards: KLF8; OMA:KLF8 - orthologs
Gene location (Human) Chr. X chromosome (human) Band Xp11.21 Start 56,232,356 bp End 56,291,531 bp
Gene location (Mouse) Chr. X chromosome (mouse) Band X|X F3 Start 152,020,462 bp End 152,179,128 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of abdomen oral cavity skin of leg vagina skin of thigh popliteal artery tibial arteries skin of hip parietal pleura gingival epithelium Top expressed in placenta morula ganglionic eminence epiblast blastocyst embryo granulocyte yolk sac mesencephalon ventricular zone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding metal ion binding nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus nucleoplasm cytosol aggresome Biological process regulation of transcription, DNA-templated transcription, DNA-templated negative regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11279 245671 Ensembl ENSG00000102349 ENSMUSG00000041649 UniProt O95600 Q8BLM0 RefSeq (mRNA) NM_001159296 NM_007250 NM_001324099 NM_001324100 NM_001324102 NM_001324104 NM_001324105 NM_173780 NM_001357183 RefSeq (protein) NP_001152768 NP_001311028 NP_001311029 NP_001311031 NP_001311033 NP_001311034 NP_009181 NP_776141 NP_001344112 Location (UCSC) Chr X: 56.23 – 56.29 Mb Chr X: 152.02 – 152.18 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Interactions

KLF8 has been shown to interact with CTBP2.

Further reading

• van Vliet J, Turner J, Crossley M (May 2000). "Human Krüppel-like factor 8: a CACCC-box binding protein that associates with CtBP and represses transcription". Nucleic Acids Research. 28 (9): 1955–62. doi:10.1093/nar/28.9.1955. PMC 103308. PMID 10756197.
• Lossi AM, Laugier-Anfossi F, Depetris D, Gecz J, Gedeon A, Kooy F, Schwartz C, Mattei MG, Croquette MF, Villard L (Feb 2002). "Abnormal expression of the KLF8 (ZNF741) gene in a female patient with an X;autosome translocation t(X;21)(p11.2;q22.3) and non-syndromic mental retardation". Journal of Medical Genetics. 39 (2): 113–7. doi:10.1136/jmg.39.2.113. PMC 1735036. PMID 11836360.
• Turner J, Nicholas H, Bishop D, Matthews JM, Crossley M (Apr 2003). "The LIM protein FHL3 binds basic Krüppel-like factor/Krüppel-like factor 3 and its co-repressor C-terminal-binding protein 2". The Journal of Biological Chemistry. 278 (15): 12786–95. doi:10.1074/jbc.M300587200. PMID 12556451.
• Zhao J, Bian ZC, Yee K, Chen BP, Chien S, Guan JL (Jun 2003). "Identification of transcription factor KLF8 as a downstream target of focal adhesion kinase in its regulation of cyclin D1 and cell cycle progression". Molecular Cell. 11 (6): 1503–15. doi:10.1016/S1097-2765(03)00179-5. PMID 12820964.
• Zhang P, Basu P, Redmond LC, Morris PE, Rupon JW, Ginder GD, Lloyd JA (2006). "A functional screen for Krüppel-like factors that regulate the human gamma-globin gene through the CACCC promoter element". Blood Cells, Molecules & Diseases. 35 (2): 227–35. doi:10.1016/j.bcmd.2005.04.009. PMID 16023392.
• Wang X, Zhao J (Jan 2007). "KLF8 transcription factor participates in oncogenic transformation". Oncogene. 26 (3): 456–61. doi:10.1038/sj.onc.1209796. PMID 16832343.
• Hu JH, Navas P, Cao H, Stamatoyannopoulos G, Song CZ (Mar 2007). "Systematic RNAi studies on the role of Sp/KLF factors in globin gene expression and erythroid differentiation". Journal of Molecular Biology. 366 (4): 1064–73. doi:10.1016/j.jmb.2006.12.047. PMC 1907364. PMID 17224162.
• Wang X, Zheng M, Liu G, Xia W, McKeown-Longo PJ, Hung MC, Zhao J (Aug 2007). "Krüppel-like factor 8 induces epithelial to mesenchymal transition and epithelial cell invasion". Cancer Research. 67 (15): 7184–93. doi:10.1158/0008-5472.CAN-06-4729. PMID 17671186.

External links

• KLF8 protein, human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)