Kallikrein-11 is a protein that in humans is encoded by the KLK11 gene.[5][6][7][8][9]

KLK11
Identifiers
AliasesKLK11, PRSS20, TLSP, kallikrein related peptidase 11
External IDsOMIM: 604434; MGI: 1929977; HomoloGene: 27048; GeneCards: KLK11; OMA:KLK11 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001136032
NM_001167605
NM_006853
NM_144947

NM_001177373
NM_019974

RefSeq (protein)

NP_001129504
NP_001161077
NP_006844
NP_659196

NP_001170844
NP_064358

Location (UCSC)Chr 19: 51.02 – 51.03 MbChr 7: 43.42 – 43.43 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in two transcript variants encoding two different isoforms which are differentially expressed.[9]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000167757Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000067616Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Yoshida S, Taniguchi M, Suemoto T, Oka T, He X, Shiosaka S (Oct 1998). "cDNA cloning and expression of a novel serine protease, TLSP". Biochim Biophys Acta. 1399 (2–3): 225–8. doi:10.1016/s0167-4781(98)00116-x. PMID 9765601.
  6. ^ Yousef GM, Scorilas A, Diamandis EP (Apr 2000). "Genomic organization, mapping, tissue expression, and hormonal regulation of trypsin-like serine protease (TLSP PRSS20), a new member of the human kallikrein gene family". Genomics. 63 (1): 88–96. doi:10.1006/geno.1999.6072. PMID 10662548.
  7. ^ Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM (Jun 2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins" (PDF). Biol Chem. 387 (6): 637–41. doi:10.1515/BC.2006.082. PMID 16800724. S2CID 436200.
  8. ^ Diamandis EP, Deperthes D, Lundwall Å (Jun 2006). "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3, 2005". Biol Chem. 387 (6): 635–824. doi:10.1515/BC.2006.081. PMID 16800723. S2CID 83910246.
  9. ^ a b "Entrez Gene: KLK11 kallikrein-related peptidase 11".

Further reading

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  • The MEROPS online database for peptidases and their inhibitors: S01.257