KLK12

Kallikrein-12 is a protein that in humans is encoded by the KLK12 gene.

KLK12
Identifiers
Aliases	KLK12, KLK-L5, KLKL5, kallikrein related peptidase 12
External IDs	OMIM: 605539; MGI: 1916761; HomoloGene: 44690; GeneCards: KLK12; OMA:KLK12 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) Band 19q13.41 Start 51,029,092 bp End 51,035,230 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7 B3|7 28.26 cM Start 43,418,321 bp End 43,423,009 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gums gingival epithelium oral cavity cervix epithelium mucosa of pharynx body of tongue superior surface of tongue vagina minor salivary glands amniotic fluid Top expressed in esophagus lip embryo stomach skin of external ear genital tubercle skin of back aorta ascending aorta nucleus of brain More reference expression data BioGPS More reference expression data
Gene ontology Molecular function hydrolase activity serine-type peptidase activity peptidase activity serine-type endopeptidase activity Cellular component extracellular region extracellular space secretory granule Biological process proteolysis cornification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 43849 69511 Ensembl ENSG00000186474 ENSMUSG00000044430 UniProt Q9UKR0 B2RVZ0 RefSeq (mRNA) NM_019598 NM_145894 NM_145895 NM_001370125 NM_001370126 NM_001370127 NM_001370128 NM_027097 RefSeq (protein) NP_062544 NP_665901 NP_665902 NP_001357054 NP_001357055 NP_001357056 NP_001357057 NP_081373 Location (UCSC) Chr 19: 51.03 – 51.04 Mb Chr 7: 43.42 – 43.42 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in three transcript variants encoding different isoforms.

Further reading

• Diamandis EP, Yousef GM, Luo LY, et al. (2001). "The new human kallikrein gene family: implications in carcinogenesis". Trends Endocrinol. Metab. 11 (2): 54–60. doi:10.1016/S1043-2760(99)00225-8. PMID 10675891. S2CID 25806934.
• Yousef GM, Luo LY, Diamandis EP (2000). "Identification of novel human kallikrein-like genes on chromosome 19q13.3-q13.4". Anticancer Res. 19 (4B): 2843–52. PMID 10652563.
• Harvey TJ, Hooper JD, Myers SA, et al. (2001). "Tissue-specific expression patterns and fine mapping of the human kallikrein (KLK) locus on proximal 19q13.4". J. Biol. Chem. 275 (48): 37397–406. doi:10.1074/jbc.M004525200. PMID 10969073.
• Yousef GM, Chang A, Scorilas A, Diamandis EP (2000). "Genomic organization of the human kallikrein gene family on chromosome 19q13.3-q13.4". Biochem. Biophys. Res. Commun. 276 (1): 125–33. doi:10.1006/bbrc.2000.3448. PMID 11006094.
• Gan L, Lee I, Smith R, et al. (2001). "Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region". Gene. 257 (1): 119–30. doi:10.1016/S0378-1119(00)00382-6. PMID 11054574.
• Yousef GM, Magklara A, Diamandis EP (2001). "KLK12 is a novel serine protease and a new member of the human kallikrein gene family-differential expression in breast cancer". Genomics. 69 (3): 331–41. doi:10.1006/geno.2000.6346. PMID 11056051.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. Bibcode:2004Natur.428..529G. doi:10.1038/nature02399. PMID 15057824.
• Shinmura K, Tao H, Yamada H, et al. (2005). "Splice-site genetic polymorphism of the human kallikrein 12 (KLK12) gene correlates with no substantial expression of KLK12 protein having serine protease activity". Hum. Mutat. 24 (3): 273–4. doi:10.1002/humu.9270. PMID 15300858. S2CID 39475520.
• Memari N, Jiang W, Diamandis EP, Luo LY (2007). "Enzymatic properties of human kallikrein-related peptidase 12 (KLK12)". Biol. Chem. 388 (4): 427–35. doi:10.1515/BC.2007.049. PMID 17391064. S2CID 25034775.

External links

• The MEROPS online database for peptidases and their inhibitors: S01.020