KSR2

For the cruise missile, see KSR-2.

The KSR2 gene (also called "The fat gene") is Kinase suppressor of ras 2 it is a protein that in humans is encoded by the KSR2 gene. KSR2 mutation effects in humans by obesity and because KSR2 gene reduces the ERK signaling and it reduces glucose and fatty acid oxidation. KSR2 mutation reduces the glucose and fatty acid oxidation process but it makes growth factor "Epidermal growth factor (EGF)" reaction more faster to simulate cell growth and KSR2 cause insulin resistance, KSA2 gene also regulates how the body uses the energy, and it usually causes type 2 diabetes.

KSR2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2Y4I
Identifiers
Aliases	KSR2, kinase suppressor of ras 2
External IDs	OMIM: 610737; MGI: 3610315; HomoloGene: 45469; GeneCards: KSR2; OMA:KSR2 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) Band 12q24.22-q24.23 Start 117,453,012 bp End 117,968,990 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5|5 F Start 117,552,065 bp End 117,913,068 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 23 middle temporal gyrus postcentral gyrus endothelial cell entorhinal cortex superior frontal gyrus primary visual cortex buccal mucosa cell cerebellar vermis Brodmann area 46 Top expressed in zygote dentate gyrus of hippocampal formation granule cell primary visual cortex superior frontal gyrus cerebellar cortex secondary oocyte lumbar subsegment of spinal cord neural layer of retina hippocampus proper amygdala More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity nucleotide binding protein serine/threonine kinase activity ATP binding metal ion binding kinase activity protein kinase activity signal transducer activity protein binding Cellular component cytoplasm membrane cytosol plasma membrane Biological process intracellular signal transduction phosphorylation protein phosphorylation Ras protein signal transduction calcium-mediated signaling positive regulation of MAPK cascade positive regulation of cold-induced thermogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 283455 333050 Ensembl ENSG00000171435 ENSMUSG00000061578 UniProt Q6VAB6 Q3UVC0 RefSeq (mRNA) NM_173598 NM_001034873 NM_001114545 NM_001312914 RefSeq (protein) NP_775869 NP_001299843 Location (UCSC) Chr 12: 117.45 – 117.97 Mb Chr 5: 117.55 – 117.91 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

KSR2 is also important in other organisms and for other biological processes. For example, in the beetle Colaphellus bowringi, KSR2 promotes ovarian development.