Kapodistrias may refer to:
- Ioannis Kapodistrias, Greek diplomat and Foreign Minister of the Russian Empire and later the first head of state of independent Greece
- Augustinos Kapodistrias, Greek soldier and politician
- Capodistria, the Italian name of the city of Koper, Slovenia
- the 1997 Kapodistrias reform of local government in Greece
- Kapodistrias Museum located in Corfu