This family represents the Kaposi's sarcoma-associated herpesvirus (KSHV) internal ribosome entry site (IRES) present in the vCyclin gene. The vCyclin and vFLIP coding sequences are present on a bicistronic transcript and it is thought the IRES may initiate translation of vFLIP from this bicistronic transcript.[1][2]
| Kaposi's sarcoma-associated herpesvirus internal ribosome entry site (IRES) | |
|---|---|
 Predicted secondary structure and sequence conservation of IRES_KSHV | |
| Identifiers | |
| Symbol | IRES_KSHV |
| Rfam | RF00511 |
| Other data | |
| RNA type | Cis-reg; IRES |
| Domain(s) | Viruses |
| GO | GO:0043022 |
| SO | SO:0000243 |
| PDB structures | PDBe |
References
edit- ^ Bieleski L, Talbot SJ (February 2001). "Kaposi's sarcoma-associated herpesvirus vCyclin open reading frame contains an internal ribosome entry site". Journal of Virology. 75 (4): 1864–1869. doi:10.1128/JVI.75.4.1864-1869.2001. PMC 114096. PMID 11160685.
- ^ Bieleski L, Hindley C, Talbot SJ (March 2004). "A polypyrimidine tract facilitates the expression of Kaposi's sarcoma-associated herpesvirus vFLIP through an internal ribosome entry site". The Journal of General Virology. 85 (Pt 3): 615–620. doi:10.1099/vir.0.19733-0. PMID 14993645.
External links
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