Katharine Hope Coward was a British pharmacologist and early adopter of chromatographic techniques.
Katharine Hope Coward | |
|---|---|
| Born | 2 July 1885 |
| Died | 8 July 1978 (aged 93) |
| Education | |
| Known for | Vitamin A research |
Early life and education
editCoward was born on 2 July 1885 in Blackburn, Lancashire. She studied Botany and graduated M.Sc. from University of Manchester.[1] After a few years, she joined University College London to study biochemistry and perform research under J. C. Drummond on Vitamin A, paving the way for her to be nominated to the Fellow of the Chemical Society in 1923.
Career
editIn 1925, Coward received a Rockefeller Fellowship to continue her studies and research on vitamin A in the Department of Agricultural Chemistry at the University of Wisconsin–Madison under Dr. Harry Steenbock. On her return to Britain, she was appointed head of the Nutrition Department of the Royal Pharmaceutical Society's pharmacological laboratories, the position which she remained until her retirement in 1950.[2] In 1937 she was elected as an honorary member of the Pharmaceuticals Society.
Chromatographic study of carotenoids
editBecause of her interest in nutrition and nutrients, Coward was one of the early adopters of chromatography following its introduction in 1906-1911 by Mikhail Tsvet.
Carotenoids, a class of structurally similar pigment molecules that include carotenes and xanthophylls, were of particular interest in nutritional research due to their demonstrated importance in animal studies. In his pioneering chromatographic research, Tsvet showed the presence of four different xanthophylls in his studies of plant extracts, separated through the use of adsorption chromatography. Following L. S. Palmer's descriptions of Tsvet's experiment in 1922, Coward replicated the methodology, the results of which she published in 1923.[3] During these studies Coward noted the presence of additional pigment (which would later be determined to be carotenes) in the eluent fractions, nearly developing a chromatographic method for the isolation of vitamin A from the carotenoids. This experiment made her the fifth scientist to adopt the use of chromatography, during a "dormant" period before the techniques popularization in the 1930s.[1]
This early research applying adsorption chromatography would continue in her role at the Royal Pharmaceutical Society, in conjunction with other analytical methods.[1]
Death
editCoward died at the age of 93 on 8 July 1978.[citation needed]
References
edit- ^ a b c Ettre, L. S.; Morris, P. J. T. (1 December 2004). "Katharine Hope Coward: A Pioneering User of Chromatography". Chromatographia. 60 (11): 613–617. doi:10.1365/s10337-004-0424-4. ISSN 1612-1112.
- ^ Rayner-Canham, Marelene; Rayner-Canham, Geoffrey (2008). Chemistry Was Their Life: Pioneering British Women Chemists. Imperial College Press. ISBN 9781860949876.
- ^ Coward, Katharine Hope (1 January 1923). "The Association of Vitamin A with the Lipochromes of Plant Tissues". Biochemical Journal. 17 (1): 145–156. doi:10.1042/bj0170145. ISSN 0306-3283. PMC 1259329. PMID 16743157.