Wikipedia

Katherine A. Fitzgerald

Katherine A. Fitzgerald is an Irish-born American molecular biologist and virologist.[1] She is a professor of medicine currently working in the Division of Infectious Disease at the University of Massachusetts Medical School. She is also the director of the Program in Innate Immunity.[2]

Katherine Fitzgerald
Born
Katherine A. Fitzgerald

Ireland
CitizenshipUnited States of America
Alma materUniversity College Cork,
Trinity College Dublin
Scientific career
ThesisSignal transduction processes regulating CD44 expression and CD44-mediated changes in pro-inflammatory gene expression (1999)

Education

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Fitzgerald received her B.Sc. degree in biochemistry in 1995 from University College Cork.[1] She received her Ph.D. in 1999 from Trinity College Dublin,[3] studying with Luke O'Neill.[1] Following her Ph.D., she was postdoc at Trinity College Dublin until 2004 when she moved to the University of Massachusetts Medical School.[4]

Research

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Fitzgerald is known for her research in the field of innate immunity and the biology behind inflammatory responses in diseases.[5] She conducts research on many aspects of innate immunity such as the molecular basis of pathogen recognition,[6] the innate immunity to malaria,[7] and the impact with diseases such as lupus or rheumatoid arthritis.[8] In 2021, Fitzgerald published results on an antiviral option to block replication in SARS-CoV-2, the viral agent responsible for COVID-19.[9]

Awards and honors

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In 2011, Fitzgerald was a finalist for the Vilcek Prize for Creative Promise in Biomedical Science.[10] In 2015, she was awarded the Science Foundation Ireland (SFI) St. Patrick's Day Science Medal, and she is the first woman to win the award.[11] She has been recognized by Clarivate as a Highly Cited Researcher in the field of immunology by Clarivate every year from 2014 to 2021 for being in the top 1% of authors cited in her field.[12][13] In 2020, she was admitted into the Royal Irish Academy, one of Ireland's most prestigious academic bodies,[14][15] and was elected to the American Academy of Microbiology.[16] In 2021 she was elected to the United States' National Academy of Sciences[17] and the National Academy of Medicine.[18]

Selected publications

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  • Fitzgerald, Katherine A.; Palsson-McDermott, Eva M.; Bowie, Andrew G.; Jefferies, Caroline A.; Mansell, Ashley S.; Brady, Gareth; Brint, Elizabeth; Dunne, Aisling; Gray, Pearl; Harte, Mary T.; McMurray, Diane (2001). "Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction". Nature. 413 (6851): 78–83. Bibcode:2001Natur.413...78F. doi:10.1038/35092578. ISSN 0028-0836. PMID 11544529. S2CID 4333764.
  • Fitzgerald, Katherine A.; Rowe, Daniel C.; Barnes, Betsy J.; Caffrey, Daniel R.; Visintin, Alberto; Latz, Eicke; Monks, Brian; Pitha, Paula M.; Golenbock, Douglas T. (6 October 2003). "LPS-TLR4 Signaling to IRF-3/7 and NF-κB Involves the Toll Adapters TRAM and TRIF". Journal of Experimental Medicine. 198 (7): 1043–1055. doi:10.1084/jem.20031023. ISSN 1540-9538. PMC 2194210. PMID 14517278.
  • Hornung, Veit; Ablasser, Andrea; Charrel-Dennis, Marie; Bauernfeind, Franz; Horvath, Gabor; Caffrey, Daniel. R.; Latz, Eicke; Fitzgerald, Katherine A. (2009). "AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC". Nature. 458 (7237): 514–518. Bibcode:2009Natur.458..514H. doi:10.1038/nature07725. ISSN 0028-0836. PMC 2726264. PMID 19158675.

References

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  1. ^ a b c "Dr. Katherine A. Fitzgerald, Ph.D." The Milstein Awards. 21 June 2014. Retrieved 22 October 2019.
  2. ^ "Program in Innate Immunity". 22 October 2014. Retrieved 28 September 2020.
  3. ^ Fitzgerald, Katherine (1999). Signal transduction processes regulating CD44 expression and CD44-mediated changes in pro-inflammatory gene expression (Thesis). OCLC 842504391.
  4. ^ "Principal Investigator". UMass Chan Medical School. 23 August 2016. Retrieved 2 October 2021.
  5. ^ "Katherine Fitzgerald focuses on novel discoveries in innate immunity". University of Massachusetts Medical School. 2 August 2016. Retrieved 22 October 2019.
  6. ^ Paludan, Søren R.; Bowie, Andrew G.; Horan, Kristy A.; Fitzgerald, Katherine A. (2011). "Recognition of herpesviruses by the innate immune system". Nature Reviews Immunology. 11 (2): 143–154. doi:10.1038/nri2937. ISSN 1474-1733. PMC 3686362. PMID 21267015.
  7. ^ Gazzinelli, Ricardo T.; Kalantari, Parisa; Fitzgerald, Katherine A.; Golenbock, Douglas T. (2014). "Innate sensing of malaria parasites". Nature Reviews Immunology. 14 (11): 744–757. doi:10.1038/nri3742. ISSN 1474-1733. PMID 25324127. S2CID 23050925.
  8. ^ "Richter, Fitzgerald named to newly endowed chairs". UMass Medical School. 2015.
  9. ^ Humphries, Fiachra; Shmuel-Galia, Liraz; Jiang, Zhaozhao; Wilson, Ruth; Landis, Philip; Ng, Sze-Ling; Parsi, Krishna Mohan; Maehr, Rene; Cruz, John; Morales, Angel; Ramanjulu, Joshi M. (18 May 2021). "A diamidobenzimidazole STING agonist protects against SARS-CoV-2 infection". Science Immunology. 6 (59): eabi9002. doi:10.1126/sciimmunol.abi9002. PMC 8158975. PMID 34010139.
  10. ^ "The Vilcek Foundation -". www.vilcek.org. Retrieved 12 November 2015.
  11. ^ O’Connell, Claire (16 March 2015). "Irish researcher Katherine Fitzgerald receives St Patrick's Day Science Medal - Discovery | siliconrepublic.com - Ireland's Technology News Service". Silicon Republic. Retrieved 22 October 2019.
  12. ^ Megan, Bard (4 February 2016). "Fitzgerald named again in Thomson Reuters Report on most influential scientific minds".
  13. ^ Pressestelle, BVDD (January 2022). "Prof. Dirk Schadendorf als "Highly Cited Researcher" ausgezeichnet". Der Deutsche Dermatologe. 70 (1): 71. doi:10.1007/s15011-022-4872-7. ISSN 0340-8078. S2CID 246155863.
  14. ^ "Royal Irish Academy - Katherine Fitzgerald". 7 January 2020.
  15. ^ Spencer, Susan (2020). "UMMS immunologist Katherine Fitzgerald admitted to Royal Irish Academy".
  16. ^ "Katherine Fitzgerald and Sanjay Ram elected to American Academy of Microbiology". UMass Chan Medical School. 24 February 2020. Retrieved 2 October 2021.
  17. ^ "News from the National Academy of Sciences". 26 April 2021. Retrieved 2 July 2021. Newly elected members and their affiliations at the time of election are: ... Fitzgerald, Katherine A.; professor, department of medicine, and Worcester Foundation for Biomedical Research Chair, University of Massachusetts Medical School, Worcester
  18. ^ "National Academy of Medicine Elects 100 New Members". National Academy of Medicine. 18 October 2021. Retrieved 18 October 2021.
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