Kelch-like protein 12

Kelch-like protein 12 is a protein that in humans is encoded by the KLHL12 gene.

KLHL12
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2VPJ
Identifiers
Aliases	KLHL12, C3IP1, DKIR, hDKIR, kelch like family member 12
External IDs	OMIM: 614522; MGI: 2385619; HomoloGene: 23317; GeneCards: KLHL12; OMA:KLHL12 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1q32.1 Start 202,891,116 bp End 202,928,636 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1|1 E4 Start 134,383,269 bp End 134,418,756 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte mucosa of ileum myocardium of left ventricle gonad cardiac muscle tissue of right atrium middle temporal gyrus sperm ventricular zone right testis Top expressed in otolith organ utricle hand substantia nigra neural layer of retina Paneth cell granulocyte trigeminal ganglion epithelium of lens tail of embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ubiquitin-protein transferase activity protein binding identical protein binding Cellular component cytosol COPII-coated ER to Golgi transport vesicle Cul3-RING ubiquitin ligase complex intracellular membrane-bounded organelle cytoplasmic vesicle microtubule organizing center Golgi membrane COPII vesicle coat Biological process COPII vesicle coating Wnt signaling pathway protein monoubiquitination negative regulation of canonical Wnt signaling pathway vesicle-mediated transport protein ubiquitination endoplasmic reticulum to Golgi vesicle-mediated transport neural crest formation neural crest cell development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 59349 240756 Ensembl ENSG00000117153 ENSMUSG00000026455 UniProt Q53G59 Q8BZM0 RefSeq (mRNA) NM_001303051 NM_001303109 NM_021633 NM_153128 NM_001311136 RefSeq (protein) NP_001289980 NP_001290038 NP_067646 NP_001298065 NP_694768 Location (UCSC) Chr 1: 202.89 – 202.93 Mb Chr 1: 134.38 – 134.42 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Interactions

KLHL12 has been shown to interact with RIT1 and CUL3.

Further reading

• Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Mai A, Jung SK, Yonehara S (October 2004). "hDKIR, a human homologue of the Drosophila kelch protein, involved in a ring-like structure". Experimental Cell Research. 300 (1): 72–83. doi:10.1016/j.yexcr.2004.06.023. PMID 15383316.
• Uchida K, Akita Y, Matsuo K, Fujiwara S, Nakagawa A, Kazaoka Y, et al. (September 2005). "Identification of specific autoantigens in Sjögren's syndrome by SEREX". Immunology. 116 (1): 53–63. doi:10.1111/j.1365-2567.2005.02197.x. PMC 1802401. PMID 16108817.
• Angers S, Thorpe CJ, Biechele TL, Goldenberg SJ, Zheng N, MacCoss MJ, Moon RT (April 2006). "The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-beta-catenin pathway by targeting Dishevelled for degradation". Nature Cell Biology. 8 (4): 348–57. doi:10.1038/ncb1381. PMID 16547521. S2CID 7270083.
• Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, et al. (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.