Kelch-like protein 2

Kelch-like family member 2 is a protein that in humans is encoded by the KLHL2 gene.

KLHL2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2XN4, 4CHB
Identifiers
Aliases	KLHL2, ABP-KELCH, MAV, MAYVEN, kelch like family member 2
External IDs	OMIM: 605774; MGI: 1924363; HomoloGene: 21416; GeneCards: KLHL2; OMA:KLHL2 - orthologs
Gene location (Human) Chr. Chromosome 4 (human) Band 4q32.3 Start 165,207,561 bp End 165,323,156 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8|8 B3.1 Start 65,192,709 bp End 65,302,669 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 23 Region I of hippocampus proper postcentral gyrus optic nerve external globus pallidus superior frontal gyrus middle temporal gyrus dorsal motor nucleus of vagus nerve Brodmann area 46 orbitofrontal cortex Top expressed in olfactory tubercle nucleus accumbens dentate gyrus subdivision of hippocampus globus pallidus Region I of hippocampus proper primary motor cortex hippocampus proper piriform cortex cumulus cell More reference expression data BioGPS n/a
Gene ontology Molecular function ubiquitin-protein transferase activity protein binding actin binding identical protein binding Cellular component ruffle cell projection actin cytoskeleton lamellipodium cytoskeleton cytoplasm Cul3-RING ubiquitin ligase complex cytosol Biological process protein ubiquitination post-translational protein modification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11275 77113 Ensembl ENSG00000109466 ENSMUSG00000031605 UniProt O95198 Q8JZP3 RefSeq (mRNA) NM_001161521 NM_001161522 NM_007246 NM_001331023 NM_001331024 NM_178633 RefSeq (protein) NP_001154993 NP_001154994 NP_001317952 NP_001317953 NP_009177 NP_848748 Location (UCSC) Chr 4: 165.21 – 165.32 Mb Chr 8: 65.19 – 65.3 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Tseng LA, Bixby JL (Aug 2011). "Interaction of an intracellular pentraxin with a BTB-Kelch protein is associated with ubiquitylation, aggregation and neuronal apoptosis". Molecular and Cellular Neurosciences. 47 (4): 254–64. doi:10.1016/j.mcn.2011.04.005. PMC 3137755. PMID 21549840.
• Korutla L, Wang P, Jackson TG, Mackler SA (2009). "NAC1, a POZ/BTB protein that functions as a corepressor". Neurochemistry International. 54 (3–4): 245–52. doi:10.1016/j.neuint.2008.12.008. PMID 19121354. S2CID 23462562.
• Williams SK, Spence HJ, Rodgers RR, Ozanne BW, Fitzgerald U, Barnett SC (Sep 2005). "Role of Mayven, a kelch-related protein in oligodendrocyte process formation". Journal of Neuroscience Research. 81 (5): 622–31. doi:10.1002/jnr.20588. PMID 16035103. S2CID 31895360.
• Dhanoa BS, Cogliati T, Satish AG, Bruford EA, Friedman JS (2013). "Update on the Kelch-like (KLHL) gene family". Human Genomics. 7 (1): 13. doi:10.1186/1479-7364-7-13. PMC 3658946. PMID 23676014.
• Mai A, Jung SK, Yonehara S (Oct 2004). "hDKIR, a human homologue of the Drosophila kelch protein, involved in a ring-like structure". Experimental Cell Research. 300 (1): 72–83. doi:10.1016/j.yexcr.2004.06.023. PMID 15383316.
• Schumacher FR, Sorrell FJ, Alessi DR, Bullock AN, Kurz T (Jun 2014). "Structural and biochemical characterization of the KLHL3-WNK kinase interaction important in blood pressure regulation". The Biochemical Journal. 460 (2): 237–46. doi:10.1042/BJ20140153. PMC 4019986. PMID 24641320.
• Soltysik-Espanola M, Rogers RA, Jiang S, Kim TA, Gaedigk R, White RA, Avraham H, Avraham S (Jul 1999). "Characterization of Mayven, a novel actin-binding protein predominantly expressed in brain". Molecular Biology of the Cell. 10 (7): 2361–75. doi:10.1091/mbc.10.7.2361. PMC 25454. PMID 10397770.
• Bu X, Avraham HK, Li X, Lim B, Jiang S, Fu Y, Pestell RG, Avraham S (Mar 2005). "Mayven induces c-Jun expression and cyclin D1 activation in breast cancer cells". Oncogene. 24 (14): 2398–409. doi:10.1038/sj.onc.1208466. PMID 15735724.
• Takahashi D, Mori T, Wakabayashi M, Mori Y, Susa K, Zeniya M, Sohara E, Rai T, Sasaki S, Uchida S (Aug 2013). "KLHL2 interacts with and ubiquitinates WNK kinases". Biochemical and Biophysical Research Communications. 437 (3): 457–62. doi:10.1016/j.bbrc.2013.06.104. PMID 23838290.