Ketocaine (INN) (brand name Vericaina, former developmental code name Astra 2358 or A-2358) is an amino ether local anesthetic of the butyrophenone family used topically for pain relief. It is marketed in Italy.[1][2][3]
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| ECHA InfoCard | 100.012.847 |
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| Formula | C18H29NO2 |
| Molar mass | 291.435 g·mol−1 |
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Synthesis
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Williamson ether synthesis between 2'-hydroxybutyrophenone [2887-61-8] (1) and diisopropylaminoethyl chloride hydrochloride [4261-68-1] (2) gives Ketocaine (3)..
References
edit- ^ Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 720–. ISBN 978-1-4757-2085-3. Archived from the original on 10 January 2023. Retrieved 3 October 2016.
- ^ Morton IK, Hall JM (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. pp. 159–. ISBN 978-94-011-4439-1.
- ^ Woolfson D, McCafferty D (1 March 1993). Percutaneous Local Anaesthesia. CRC Press. pp. 88–. ISBN 978-0-13-656372-3.
- ^ Da Re, Paolo.; Verlicchi, Lucia.; Setnikar, Ivo. (1967). "β-Phenoxyethylamines with Local Anesthetic and Antispasmodic Activity". Journal of Medicinal Chemistry. 10 (2): 266–270. doi:10.1021/jm00314a036.
- ^ Re Paolo Da, Setnikar Ivo, U.S. patent 3,335,184 (1967 to S Chemiques Et Pharma Seceph S).
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