Wikipedia

Kevin Lustig

Kevin Donald Lustig (born 23 August 1963) is an American scientist and entrepreneur and founder of three life science companies: the pharmaceutical company Kalypsys in 2001; the online research marketplace Scientist.com (formerly Assay Depot) in 2007; and the non-profit lab incubator Bio, Tech and Beyond in 2013.[1][2][3][4][5][6][7]

Kevin Lustig
Born (1963-08-23) August 23, 1963 (age 61)
Jamaica, New York
NationalityAmerican
Alma materUniversity of California, San Francisco
University of Missouri
Cornell University
Known forDrug discovery, High-throughput screening (HTS), Founder and CEO of Scientist.com
Scientific career
InstitutionsHarvard Medical School
Thesis Functional Analyses of Vertebrate Signaling Pathways
Doctoral advisorMarc Kirschner

Education

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Lustig received an A.B. degree, magna cum laude, from the Section of Biochemistry, Molecular and Cell Biology from Cornell University in 1985. He received an M.S. degree in Biochemistry from the University of Missouri in 1991 and a PhD degree from Marc Kirschner’s laboratory in the Department of Biochemistry and Biophysics at the University of California, San Francisco in 1997.[8] Lustig carried out postdoctoral research in the Department of Cell Biology at Harvard Medical School in 1997.

Scientific contributions

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Lustig has published 25 original research articles, 4 book chapters and holds 8 patents.[9][10]

In 1993, Lustig and Andrew Shiau cloned the first member of a novel class of Purinergic receptors activated by extracellular adenosine triphosphate (ATP), a gene family that includes important drug targets.[11]

In 1993, Lustig and Bruce Conklin invented the first of a series of G-protein chimeras that are still widely used by the pharmaceutical and biotechnology industry for drug screening.[12][13][14]

In 1996, Lustig and Marc Kirschner invented a paracrine signaling assay and used it to identify Xnr1, which is part of a cell signaling pathway generating left-right asymmetry.[15][16]

In 1997, Lustig and Randy King invented an in vitro expression cloning technology used to isolate substrates of kinases and proteases.[17][18][19][20]

In 1997, Lustig invented a functional genomics approach to gene discovery and used it to identify a new member of the T-box family of transcription factors (Xombi aka VegT).[21]

In 1999 and 2000, Lustig and colleagues showed that bile acids are physiological ligands for the farnesoid X receptor (FXR), invented synthetic liver X receptor (LXR) agonists, and demonstrated that both FXR and LXR ligands regulate cholesterol transport.[22][23][24][25]

Entrepreneurial career

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Lustig served as a research director at the biotechnology company Tularik, Inc. from 1997 to 2001, before it being acquired by Amgen in 2004.[26][27][28] Tularik went public in December 1999 and is credited with helping to start the biotechnology stock bubble of 2000.[29][30]

Lustig, Randy King, Pratik Shah and Peter Schultz founded the pharmaceutical company Kalypsys, Inc. in 2001.[2] The company was a pioneer in using high throughput screening (HTS) for phenotypic drug screens.[31] The company raised over $170M in venture capital funding.[32] The HTS part of the business was sold to Wako Chemicals USA in 2010.[33]

In 2007, Lustig, Chris Petersen, and Andrew Martin founded the research marketplace Assay Depot (later Scientist.com).[3][4][5] The company launched its first public marketplace in September 2008. In 2011 and 2012, Scientist.com launched outsourcing marketplaces for the large pharmaceutical companies Pfizer and AstraZeneca, respectively.[34][35][36][37] By 2020, the company operated private marketplaces for most of the world’s major pharmaceutical companies and US National Institutes of Health (NIH).[38] In late 2020, Scientist.com acquired HealthEconomics.Com, the world’s leading ConnectedCommunity in the Value, Evidence and Access space.[39] Then, in 2021, Scientist.com completed three additional acquisitions, one of which was InsideScientific, an online environment that facilitates the exchange of scientific information via webinars, podcasts, and more.[40] Next, was Notch8, which provides software and app development services, and have since rebranded as Scientist.com Software Solutions.[41] Lastly, is BioPharmCatalyst, an online resource for stock market investors of publicly traded biotechnology and pharmaceutical companies listed on U.S. markets NASDAQ and New York Stock Exchange (NYSE).[42]

Lustig and Joseph Jackson founded Bio, Tech and Beyond (BTNB), a non-profit life science incubator in Carlsbad, California in 2013; BTNB is a fully equipped shared research facility that makes it possible for one or a few scientists to start a life science company without significant funding.[43][44]

Recognition

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In 2013, Lustig was named “San Diego’s Most Admired CEO” by the San Diego Business Journal.[45] That same year he was also one of five national finalists for Entrepreneur magazine's Emerging Entrepreneur of the Year Award.[46] Lustig was twice recognized as one of the life science industry’s “100 Most Inspiring People” by PharmaVoice magazine in 2012 and 2013.[47][48] The company also won the San Diego Business Journal’s 2014 Innovation Award.[49] In 2015, 2018, and 2019, the company was named one of Entrepreneur magazine’s Best Entrepreneurial Companies in America.[50][51] From 2017-2019, Scientist.com ranked number 155, 9, and 289, respectively on Inc. magazine’s list of the 500 Fastest-Growing privately-owned companies in America.[52][53] Scientist.com made Inc. magazine's list of Best Workplaces of 2018 and 2019.[54] Scientist.com was ranked as the 2nd Fastest-Growing Private Company in 2018 and the 10th Fastest-Growing Private Company in 2019 by the San Diego Business Journal,[55][56][57] and in 2020 it named Lustig as one of San Diego's Most Influential People.[58] In 2023, Scientist.com was named as America's 11th Most Innovative Company by Fortune.

Notes and references

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  1. ^ Wagner, David (7 December 2015). "Study: Shelved San Diego Drug Could Fight Deadly Brain Disease". KPBS. Retrieved 19 August 2016.
  2. ^ a b "Kalypsys Raises $43 Million in Series A Financing". Evaluate Group. 2 April 2002. Retrieved 19 August 2016.[dead link‍]
  3. ^ a b Bigelow, Bruce V. (17 December 2009). "Assay Depot Founders Morphed Their Biotech Startup Into e-Commerce Provider of Drug Discovery Services". Xconomy. Retrieved 6 August 2016.
  4. ^ a b Akst, Jeff (1 February 2010). "The Matchmaking Market". The Scientist. Retrieved 6 August 2016.
  5. ^ a b Taylor, Phil (16 September 2008). "Assay Depot: 'Ebay' of Drug Discovery Services Debuts". Outsourcing-Pharma.com. Archived from the original on 12 October 2013. Retrieved 22 August 2016.
  6. ^ Burke, Megan; St. John, Alison (11 July 2013). "Biotech Incubator Opens In North County". KPBS.org. KPBS. Retrieved 19 August 2016.
  7. ^ Bigelow, Bruce V. (28 October 2015). "Early Biotech Startups Take Stage at Carlsbad Bio Incubator". Xconomy. Retrieved 19 August 2016.
  8. ^ Functional Analyses of Vertebrate Signaling Pathways. 1997. ISBN 9780591486179 – via UCSF Library.
  9. ^ "Search Results". PubMed.gov. Retrieved 19 August 2016.
  10. ^ "Search Results". Google Patents. Retrieved 19 August 2016.
  11. ^ Erb, L; Lustig, KD; Sullivan, DM; Turner, JT; Weisman, GA (15 November 1993). "Functional Expression and Photoaffinity Labeling of a Cloned P2U Purinergic Receptor". Proceedings of the National Academy of Sciences. 90 (22): 10449–53. Bibcode:1993PNAS...9010449E. doi:10.1073/pnas.90.22.10449. PMC 47794. PMID 8248130.
  12. ^ Conklin, BR; Farfel, Z; Lustig, KD; Julius, D; Bourne, HR (20 May 1993). "Substitution of Three Amino Acids Switches Receptor Specificity of Gq Alpha to that of Gi Alpha". Nature. 363 (6426): 274–6. Bibcode:1993Natur.363..274C. doi:10.1038/363274a0. PMID 8387644. S2CID 4350799.
  13. ^ "G Protein Chimera User Manual". Openwetware.org. OpenWetWare. Retrieved 19 August 2016.
  14. ^ "LiveWare". moleculardevices.com. Molecular Devices. Retrieved 19 August 2016.
  15. ^ Lustig, KD; Kroll, K; Sun, E; Ramos, R; Elmendorf, H; Kirschner, M (October 1996). "A Xenopus Nodal-Related Gene That Acts in Synergy with Noggin to Induce Complete Secondary Axis and Notochord Formation". Development. 122 (10): 3275–82. doi:10.1242/dev.122.10.3275. PMID 8898239.
  16. ^ "U.S. Patent Number 5,585,087" (PDF). Google Patents. Retrieved 21 August 2016.
  17. ^ King, RW; Lustig, KD; Stukenberg, PT; McGarry, TJ; Kirschner, MW (15 August 1997). "Expression Cloning in the Test Tube". Science. 277 (5328): 973–4. doi:10.1126/science.277.5328.973. PMID 9281074. S2CID 84899326.
  18. ^ Lustig, KD; Stukenberg, PT; McGarry, TJ; King, RW; Cryns, VL; Mead, PE; Zon, LI; Yuan, J; Kirschner, MW (1997). "Small pool expression screening: Identification of genes involved in cell cycle control, apoptosis, and early development". Cell Cycle Control. Methods in Enzymology. Vol. 283. pp. 83–99. doi:10.1016/S0076-6879(97)83009-1. ISBN 9780121821845. PMID 9251013.
  19. ^ Stukenberg, PT; Lustig, KD; McGarry, TJ; King, RW; Yuang, J; Kirschner, MW (1 May 1997). "Systematic Identification of Mitotic Phosphoproteins". Current Biology. 7 (5): 338–48. Bibcode:1997CBio....7..338S. doi:10.1016/s0960-9822(06)00157-6. PMID 9115395. S2CID 1137184.
  20. ^ Mead, PE; Zhou, Y; Lustig, KD; Huber, TL; Kirschner, MW; Zon, LI (15 September 1998). "Cloning of Mix-Related Homeodomain Proteins Using Fast Retrieval of Gel Shift Activities, (FROGS), a Technique for the Isolation of DNA-Binding Proteins". Proceedings of the National Academy of Sciences. 95 (19): 11251–6. Bibcode:1998PNAS...9511251M. doi:10.1073/pnas.95.19.11251. PMC 21628. PMID 9736722.
  21. ^ Lustig, KD; Kroll, KL; Sun, EE; Kirschner, MW (December 1996). "Expression Cloning of a Xenopus T-Related Gene (Xombi) Involved in Mesodermal Patterning and Blastopore Lip Formation". Development. 122 (12): 4001–12. doi:10.1242/dev.122.12.4001. PMID 9012520.
  22. ^ Makishima, M; Okamoto, AY; Repa, JJ; Tu, H; Learned, RM; Luk, A; Hull, MV; Lustig, KD; Mangelsdorf, DJ; Shan, B (21 May 1999). "Identification of a Nuclear Receptor for Bile Acids". Science. 284 (5418): 1362–5. Bibcode:1999Sci...284.1362M. doi:10.1126/science.284.5418.1362. PMID 10334992.
  23. ^ Schultz, JR; Tu, H; Luk, A; Repa, JJ; Medina, JC; Schwendner, L; Wang, S; Thoolen, M; Manglesdorf, DJ; Lustig, KD; Shan, B (15 November 2000). "Role of LXRs in Control of Lipogenesis". Genes & Development. 14 (22): 2831–8. doi:10.1101/gad.850400. PMC 317060. PMID 11090131.
  24. ^ "U.S. Patent Number 6,555,326" (PDF). Google Patents. Retrieved 21 August 2016.
  25. ^ "U.S. Patent Number 6,316,503" (PDF). Google Patents. Retrieved 21 August 2016.
  26. ^ Gellene, Denise (30 March 2004). "Amgen to Buy Rival Tularik". Los Angeles Times. Retrieved 21 August 2016.
  27. ^ Wilson, Heather (13 August 2004). "Amgen Completes Tularik Acquisition". MarketWatch. CBS MarketWatch. Retrieved 21 August 2016.
  28. ^ "Scientist.com About Us". Scientist.com. Retrieved 21 August 2016.
  29. ^ Hall, Carl T. (17 October 1996). "A Big Bet on Biotech: Tularik Turns to Private Hands for $60 million". SF Gate. Hearst Communications. Retrieved 21 August 2016.
  30. ^ Slud, Martha (22 February 2000). "Boom Time for Biotech". CNN Money. Time Warner. Retrieved 21 August 2016.
  31. ^ Sam, Michael; et al. (October 2008). "A Robotic Platform for Quantitative High-Throughput Screening". Assay Drug Development Technology. 6 (5): 637–57. doi:10.1089/adt.2008.150. PMC 2651822. PMID 19035846.
  32. ^ "Kalypsys Raises $100 Million in Series C Financing". San Diego Source. 29 November 2006. Retrieved 21 August 2016.
  33. ^ "A Brief History of Wako Chemicals USA". wakousa. Retrieved February 6, 2023.
  34. ^ "Xconomy: San Diego's Assay Depot Unveils Online Exchange for AstraZeneca's R&D". Xconomy. 2012-07-30. Retrieved 2022-06-28.
  35. ^ "Xconomy: San Diego's Assay Depot Creates Private e-Commerce Sites for Pfizer, Other Big Pharmas". Xconomy. 2011-07-12. Retrieved 2022-06-28.
  36. ^ "AstraZeneca launches virtual research laboratory | Pharmafile". www.pharmafile.com. 31 July 2012. Retrieved 2022-06-28.
  37. ^ "AstraZeneca goes virtual". Drug Discovery News. Retrieved 2022-06-28.
  38. ^ Cheng, Michelle (15 August 2018). "Meet the Startup That's Building the Amazon for Scientists". Inc.com. Inc. magazine. Retrieved 8 January 2020.
  39. ^ "Scientist.com to Acquire HealthEconomics.Com, the World's Leading Connected Community for Health Economics and Outcomes Research". www.businesswire.com. 2020-12-15. Retrieved 2022-06-28.
  40. ^ "Scientist.com Announces Acquisition of InsideScientific, a Life Science Webinar, Virtual Event and Content Creation Company". www.businesswire.com. 2021-09-14. Retrieved 2022-06-28.
  41. ^ "Scientist.com Expands Science as a Service® Platform with Acquisition of Notch8". www.businesswire.com. 2022-03-29. Retrieved 2022-06-28.
  42. ^ "2021 Year in Review". Scientist.com. 17 January 2022. Retrieved 2022-06-28.
  43. ^ Burke, Megan; St John, Alison (11 July 2013). "Biotech Incubator Opens In North County". KPBS. Retrieved 21 August 2016.
  44. ^ Bigelow, Bruce V. (28 October 2015). "Early Biotech Startups Take Stage at Carlsbad Bio Incubator". Xconomy. Retrieved 21 August 2016.
  45. ^ "Most Admired CEO 2013" (PDF). San Diego Business Journal. Retrieved 7 August 2016.
  46. ^ Davis, Kathleen (7 August 2013). "Who Will Win Our Emerging Entrepreneur of 2013 Contest? Help Decide". Entrepreneur. Entrepreneur magazine. Retrieved 7 August 2016.
  47. ^ Grom, Teran (July–August 2012). "PharmaVOICE 100: Who's on the List by Section". PharmaVOICE. Retrieved 7 August 2016.
  48. ^ "The 100 Most Inspiring People". PharmaVOICE. July–August 2013. Retrieved 7 August 2016.
  49. ^ "2014 San Diego Business Journal Innovation Awards" (PDF). cbjonline.com. San Diego Business Journal. Retrieved 7 August 2016.
  50. ^ Shea, Ryan (7 October 2015). "What Sets Apart the Best Entrepreneurial Companies in America". Entrepreneur. Entrepreneur magazine. Retrieved 7 August 2016.
  51. ^ "Entrepreneur360 List". Entrepreneur.com. Entrepreneur magazine. Retrieved 26 December 2019.
  52. ^ "Drug Research Is Slow and Expensive. These Scientists Came Up With an Idea to Change That". Inc.com. 2018-08-15. Retrieved 2018-08-30.
  53. ^ "Inc. 5000 2017 Full List". Inc. 5000. Inc. Magazine. Retrieved 5 October 2017.
  54. ^ "Scientist.com profile". Inc. magazine. Retrieved 26 December 2019.
  55. ^ "Fast 100 #2 Scientist.com". YouTube. San Diego Business Journal. 31 July 2018. Retrieved 26 December 2019.
  56. ^ "SDBJ Announces the Fastest 100 Growing Private Cos. List". San Diego Business Journal. Retrieved 2018-07-31.
  57. ^ "The List: Fastest-Growing Private Companies" (PDF). sdbj.com. San Diego Business Journal. Retrieved 26 December 2019.
  58. ^ "SD500: Kevin Lustig". sdbj.com. San Diego Business Journal. 26 February 2019. Retrieved 29 December 2019.
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