Khalisa may refer to:
- Khalsa, derived from Arabic: Khalisa, meaning pure
- Khalistan, meaning "Land of the pure"
- Kalsa, historically known as Khalisa, a quarter in the Italian city of Palermo
- Noyakert, formerly known as Khalisa, a town in Armenia
- Khalisa, a neighbourhood of the Israeli city of Haifa
- al-Khalisa, a former village in Palestine